Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Predicting Transdermal Uptake of Phthalates and a Paraben from Cosmetic Cream Using the Measured Fugacity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Dermal Uptake of Benzophenone-3 from Clothing

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Predictors of polychlorinated biphenyl concentrations in adipose tissue in a general Danish population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Experimentally determined human respiratory tract deposition of airborne particles at a busy street

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Associations of serum phthalate metabolites with thyroid hormones in GraMo cohort, Southern Spain

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cohort profile: The COPENHAGEN Minipuberty Study-A longitudinal prospective cohort of healthy full-term infants and their parents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prenatal Exposure to Butyl Paraben Is Associated With Fat Percentage in 7-Year-Old Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Transdermal uptake models compliment in vitro and in vivo experiments in assessing risk of environmental exposures to semivolatile organic compounds (SVOCs). A key parameter for mechanistic models is the chemical driving force for mass transfer from environmental media to human skin. In this research, we measure this driving force in the form of fugacity for chemicals in cosmetic cream and use it to model uptake from cosmetics as a surrogate for condensed environmental media. A simple cosmetic cream, containing no target analytes, was mixed with diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), and butyl paraben (BP) and diluted to make creams with concentrations ranging from 0.025% to 6%. The fugacity, relative to the pure compound, was measured using solid-phase micro extraction (SPME). We found that the relationship between the concentration and fugacity is highly nonlinear. The relative fugacity of the chemicals for a 2% w/w formulation was used in a diffusion-based model to predict transdermal uptake of each chemical and was compared with excretion data from a prior human subject study with the same formulation. Dynamic simulations of excretion are generally consistent with the results of the human subject experiment but sensitive to the input parameters, especially the time between cream application and showering.

OriginalsprogEngelsk
TidsskriftEnvironmental Science & Technology
Vol/bind54
Udgave nummer12
Sider (fra-til)7471-7484
Antal sider14
ISSN0013-936X
DOI
StatusUdgivet - 16 jun. 2020

ID: 60197259