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Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates. 2. Clinical part

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Harvard

Heiring, C, Verder, H, Schousboe, P, Jessen, TE, Bender, L, Ebbesen, F, Dahl, M, Eschen, C, Fenger-Grøn, J, Höskuldsson, A, Matthews, M, Reinholdt, J, Scoutaris, N & Smedegaard, H 2020, 'Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates. 2. Clinical part', Acta paediatrica, bind 109, nr. 2, s. 285-290. https://doi.org/10.1111/apa.14831

APA

Heiring, C., Verder, H., Schousboe, P., Jessen, T. E., Bender, L., Ebbesen, F., Dahl, M., Eschen, C., Fenger-Grøn, J., Höskuldsson, A., Matthews, M., Reinholdt, J., Scoutaris, N., & Smedegaard, H. (2020). Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates. 2. Clinical part. Acta paediatrica, 109(2), 285-290. https://doi.org/10.1111/apa.14831

CBE

Heiring C, Verder H, Schousboe P, Jessen TE, Bender L, Ebbesen F, Dahl M, Eschen C, Fenger-Grøn J, Höskuldsson A, Matthews M, Reinholdt J, Scoutaris N, Smedegaard H. 2020. Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates. 2. Clinical part. Acta paediatrica. 109(2):285-290. https://doi.org/10.1111/apa.14831

MLA

Vancouver

Author

Heiring, Christian ; Verder, Henrik ; Schousboe, Peter ; Jessen, Torben E ; Bender, Lars ; Ebbesen, Finn ; Dahl, Marianne ; Eschen, Christian ; Fenger-Grøn, Jesper ; Höskuldsson, Agnar ; Matthews, Morgaine ; Reinholdt, Jes ; Scoutaris, Nikolaos ; Smedegaard, Heidi. / Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates. 2. Clinical part. I: Acta paediatrica. 2020 ; Bind 109, Nr. 2. s. 285-290.

Bibtex

@article{3d3e5e938fdf42639d67e692cb0ef1a1,
title = "Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates. 2. Clinical part",
abstract = "AIM: To evaluate the accuracy of our new rapid point-of-care (POC) test for lung maturity. The method as we describe in an accompanying article was developed with the purpose of improving the outcome from respiratory distress syndrome (RDS). The test enables the delivery of surfactant in infants with immature lungs already at birth and ensures that infants with mature lungs are not treated unnecessarily.METHODS: Fresh gastric aspirate (GAS) was sampled at birth in a cohort of preterm infants with gestational ages ranging between 24 and 31 completed weeks for lung surfactant measurement as lecithin-sphingomyelin ratio (L/S). L/S was prospectively compared with RDS development. The clinical outcome was blinded for the investigators of L/S. The time for analysis was <15 minutes.RESULTS: GAS was obtained from 72 infants. Forty-four (61%) developed RDS. The cut-off for L/S was 3.05; predicting RDS with a sensitivity of 91% and specificity of 79%.CONCLUSION: The new improved spectroscopic L/S method of lung maturity on GAS has high sensitivity. The method is designed for use as a POC test at birth, and a spectroscopic prototype has been developed for bedside use. Clinical trials with this new lung maturity test are planned.",
keywords = "Gastric aspirate, Lung surfactant, Mid-infrared spectroscopy, Prematurity, Respiratory distress syndrome",
author = "Christian Heiring and Henrik Verder and Peter Schousboe and Jessen, {Torben E} and Lars Bender and Finn Ebbesen and Marianne Dahl and Christian Eschen and Jesper Fenger-Gr{\o}n and Agnar H{\"o}skuldsson and Morgaine Matthews and Jes Reinholdt and Nikolaos Scoutaris and Heidi Smedegaard",
note = "{\textcopyright}2019 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.",
year = "2020",
month = feb,
doi = "10.1111/apa.14831",
language = "English",
volume = "109",
pages = "285--290",
journal = "Acta paediatrica",
issn = "1651-2227",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates. 2. Clinical part

AU - Heiring, Christian

AU - Verder, Henrik

AU - Schousboe, Peter

AU - Jessen, Torben E

AU - Bender, Lars

AU - Ebbesen, Finn

AU - Dahl, Marianne

AU - Eschen, Christian

AU - Fenger-Grøn, Jesper

AU - Höskuldsson, Agnar

AU - Matthews, Morgaine

AU - Reinholdt, Jes

AU - Scoutaris, Nikolaos

AU - Smedegaard, Heidi

N1 - ©2019 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

PY - 2020/2

Y1 - 2020/2

N2 - AIM: To evaluate the accuracy of our new rapid point-of-care (POC) test for lung maturity. The method as we describe in an accompanying article was developed with the purpose of improving the outcome from respiratory distress syndrome (RDS). The test enables the delivery of surfactant in infants with immature lungs already at birth and ensures that infants with mature lungs are not treated unnecessarily.METHODS: Fresh gastric aspirate (GAS) was sampled at birth in a cohort of preterm infants with gestational ages ranging between 24 and 31 completed weeks for lung surfactant measurement as lecithin-sphingomyelin ratio (L/S). L/S was prospectively compared with RDS development. The clinical outcome was blinded for the investigators of L/S. The time for analysis was <15 minutes.RESULTS: GAS was obtained from 72 infants. Forty-four (61%) developed RDS. The cut-off for L/S was 3.05; predicting RDS with a sensitivity of 91% and specificity of 79%.CONCLUSION: The new improved spectroscopic L/S method of lung maturity on GAS has high sensitivity. The method is designed for use as a POC test at birth, and a spectroscopic prototype has been developed for bedside use. Clinical trials with this new lung maturity test are planned.

AB - AIM: To evaluate the accuracy of our new rapid point-of-care (POC) test for lung maturity. The method as we describe in an accompanying article was developed with the purpose of improving the outcome from respiratory distress syndrome (RDS). The test enables the delivery of surfactant in infants with immature lungs already at birth and ensures that infants with mature lungs are not treated unnecessarily.METHODS: Fresh gastric aspirate (GAS) was sampled at birth in a cohort of preterm infants with gestational ages ranging between 24 and 31 completed weeks for lung surfactant measurement as lecithin-sphingomyelin ratio (L/S). L/S was prospectively compared with RDS development. The clinical outcome was blinded for the investigators of L/S. The time for analysis was <15 minutes.RESULTS: GAS was obtained from 72 infants. Forty-four (61%) developed RDS. The cut-off for L/S was 3.05; predicting RDS with a sensitivity of 91% and specificity of 79%.CONCLUSION: The new improved spectroscopic L/S method of lung maturity on GAS has high sensitivity. The method is designed for use as a POC test at birth, and a spectroscopic prototype has been developed for bedside use. Clinical trials with this new lung maturity test are planned.

KW - Gastric aspirate

KW - Lung surfactant

KW - Mid-infrared spectroscopy

KW - Prematurity

KW - Respiratory distress syndrome

UR - http://www.scopus.com/inward/record.url?scp=85066637161&partnerID=8YFLogxK

U2 - 10.1111/apa.14831

DO - 10.1111/apa.14831

M3 - Journal article

C2 - 31038796

VL - 109

SP - 285

EP - 290

JO - Acta paediatrica

JF - Acta paediatrica

SN - 1651-2227

IS - 2

ER -

ID: 57073643