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Post-Endoscopic Retrograde Cholangiopancreaticography complications in liver transplanted patients, a single-center experience

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@article{ef93a09d818746eda5dde4496cbb4495,
title = "Post-Endoscopic Retrograde Cholangiopancreaticography complications in liver transplanted patients, a single-center experience",
abstract = "BACKGROUND: Complications in the biliary tract occur in 5{\%}-30{\%} after liver transplantation and the main part of the complications is successfully managed with endoscopic retrograde cholangiopancreaticography (ERCP). The incidence and risk factors for post-ERCP complications in liver transplantation patients are not well described. Our objective was to define the frequency of post-ERCP complications in liver transplantation patients at the Abdominal Center, Rigshospitalet, the only Liver Transplantation Center in Denmark.METHODS: Retrospective study of all ERCPs performed in liver transplantation patients during a 9-year period.RESULTS: A total of 292 ERCPs were included. Overall post-ERCP complications occurred in 24 procedures (8.2{\%}): pancreatitis in 8 (2.7{\%}), bleeding in 5 (1.7{\%}), and cholangitis in 13 (4.5{\%}) procedures. Simultaneous pancreatitis and cholangitis, and simultaneous bleeding and cholangitis occurred after two procedures, respectively. Multivariate analysis concerning overall complications identified biliary sphincterotomy (p = 0.006) and time since liver transplantation within 90 days postoperatively (p = 0.044) as risk factors for post-ERCP complications. Specifically concerning post-ERCP pancreatitis (PEP), it was found that pre-ERCP cholangitis was another independent risk factor for PEP (p = 0.026). Stent in the biliary tract prior to ERCP seemed to be protective (p = 0.041).CONCLUSIONS: Complications were of surprisingly mild degree. The rates of post-ERCP complications in our study were in line with previous studies with liver transplantation patients. Cholangitis prior to ERCP may be another risk factor for post-ERCP pancreatitis.",
author = "Rikard Ambrus and Svendsen, {L B} and Hillings{\o}, {J G} and Hansen, {M L} and Achiam, {M P}",
year = "2015",
doi = "10.1177/1457496914529274",
language = "English",
volume = "104",
pages = "86--91",
journal = "Scandinavian Journal of Surgery",
issn = "1457-4969",
publisher = "Suomen Kirurgiyhdistyksen",
number = "2",

}

RIS

TY - JOUR

T1 - Post-Endoscopic Retrograde Cholangiopancreaticography complications in liver transplanted patients, a single-center experience

AU - Ambrus, Rikard

AU - Svendsen, L B

AU - Hillingsø, J G

AU - Hansen, M L

AU - Achiam, M P

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Complications in the biliary tract occur in 5%-30% after liver transplantation and the main part of the complications is successfully managed with endoscopic retrograde cholangiopancreaticography (ERCP). The incidence and risk factors for post-ERCP complications in liver transplantation patients are not well described. Our objective was to define the frequency of post-ERCP complications in liver transplantation patients at the Abdominal Center, Rigshospitalet, the only Liver Transplantation Center in Denmark.METHODS: Retrospective study of all ERCPs performed in liver transplantation patients during a 9-year period.RESULTS: A total of 292 ERCPs were included. Overall post-ERCP complications occurred in 24 procedures (8.2%): pancreatitis in 8 (2.7%), bleeding in 5 (1.7%), and cholangitis in 13 (4.5%) procedures. Simultaneous pancreatitis and cholangitis, and simultaneous bleeding and cholangitis occurred after two procedures, respectively. Multivariate analysis concerning overall complications identified biliary sphincterotomy (p = 0.006) and time since liver transplantation within 90 days postoperatively (p = 0.044) as risk factors for post-ERCP complications. Specifically concerning post-ERCP pancreatitis (PEP), it was found that pre-ERCP cholangitis was another independent risk factor for PEP (p = 0.026). Stent in the biliary tract prior to ERCP seemed to be protective (p = 0.041).CONCLUSIONS: Complications were of surprisingly mild degree. The rates of post-ERCP complications in our study were in line with previous studies with liver transplantation patients. Cholangitis prior to ERCP may be another risk factor for post-ERCP pancreatitis.

AB - BACKGROUND: Complications in the biliary tract occur in 5%-30% after liver transplantation and the main part of the complications is successfully managed with endoscopic retrograde cholangiopancreaticography (ERCP). The incidence and risk factors for post-ERCP complications in liver transplantation patients are not well described. Our objective was to define the frequency of post-ERCP complications in liver transplantation patients at the Abdominal Center, Rigshospitalet, the only Liver Transplantation Center in Denmark.METHODS: Retrospective study of all ERCPs performed in liver transplantation patients during a 9-year period.RESULTS: A total of 292 ERCPs were included. Overall post-ERCP complications occurred in 24 procedures (8.2%): pancreatitis in 8 (2.7%), bleeding in 5 (1.7%), and cholangitis in 13 (4.5%) procedures. Simultaneous pancreatitis and cholangitis, and simultaneous bleeding and cholangitis occurred after two procedures, respectively. Multivariate analysis concerning overall complications identified biliary sphincterotomy (p = 0.006) and time since liver transplantation within 90 days postoperatively (p = 0.044) as risk factors for post-ERCP complications. Specifically concerning post-ERCP pancreatitis (PEP), it was found that pre-ERCP cholangitis was another independent risk factor for PEP (p = 0.026). Stent in the biliary tract prior to ERCP seemed to be protective (p = 0.041).CONCLUSIONS: Complications were of surprisingly mild degree. The rates of post-ERCP complications in our study were in line with previous studies with liver transplantation patients. Cholangitis prior to ERCP may be another risk factor for post-ERCP pancreatitis.

U2 - 10.1177/1457496914529274

DO - 10.1177/1457496914529274

M3 - Journal article

VL - 104

SP - 86

EP - 91

JO - Scandinavian Journal of Surgery

JF - Scandinavian Journal of Surgery

SN - 1457-4969

IS - 2

ER -

ID: 44410214