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Poor Head Growth Is Associated with Later Mental Delay among Vietnamese Preterm Infants: A Follow-up Study

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@article{2afab3cc1f7240b0b1f7ab81b38aceb9,
title = "Poor Head Growth Is Associated with Later Mental Delay among Vietnamese Preterm Infants: A Follow-up Study",
abstract = "BACKGROUND: Preterm infants in low- and middle-income countries are at high risk of poor physical growth, but their growth data are still scarce.OBJECTIVES: To describe the growth of Vietnamese preterm infants in the first 2 years, and to compare with references: World Health Organization (WHO) child growth standards, and healthy Southeast Asian (SEA) infants. Further, to assess the association between growth in the first year and neurodevelopment at 2 years corrected age (CA).METHODS: We conducted a cohort study to follow up preterm infants discharged from a neonatal intensive care unit for 2 years. Weight, length and head circumference (HC) were measured at 3, 12 and 24 months CA. Neurodevelopment was assessed using Bayley Scales of Infant and Toddler Development-3rd Edition at 24 months CA.RESULTS: Over 90% of the cohort showed catch-up weight at 3 months CA. Weight and length were comparable to healthy SEA but were lower than WHO standards. HC was significantly smaller than those of WHO standards with HC Z-scores steadily decreasing from -0.95 at 3 months CA to -1.50 at 24 months CA. Each one decrement of HC Z-score from 3 to 12 months CA was associated with nearly twice an increase in odds of mental delay at 24 months CA (odds ratio 1.89; 95% confidence interval 1.02-3.50).CONCLUSION: Vietnamese preterm infants exhibited early catch-up weight but poor head growth, which was associated with later delays in mental development. Our findings support the importance of HC measures in follow-up for preterm infants.",
keywords = "growth, head circumference, low-resource settings, neurodevelopment, preterm, South East Asia",
author = "Do, {Chuong Huu Thieu} and B{\o}rresen, {Malene Landbo} and Pedersen, {Freddy Karup} and Nguyen, {Tinh Thu} and Nguyen, {Hung Thanh} and Kruse, {Alexandra Yasmin}",
note = "Publisher Copyright: {\textcopyright} 2020 The Author(s) [2020]. Published by Oxford University Press. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = feb,
doi = "10.1093/tropej/fmaa117",
language = "English",
volume = "67",
journal = "Journal of Tropical Pediatrics",
issn = "0142-6338",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Poor Head Growth Is Associated with Later Mental Delay among Vietnamese Preterm Infants

T2 - A Follow-up Study

AU - Do, Chuong Huu Thieu

AU - Børresen, Malene Landbo

AU - Pedersen, Freddy Karup

AU - Nguyen, Tinh Thu

AU - Nguyen, Hung Thanh

AU - Kruse, Alexandra Yasmin

N1 - Publisher Copyright: © 2020 The Author(s) [2020]. Published by Oxford University Press. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/2

Y1 - 2021/2

N2 - BACKGROUND: Preterm infants in low- and middle-income countries are at high risk of poor physical growth, but their growth data are still scarce.OBJECTIVES: To describe the growth of Vietnamese preterm infants in the first 2 years, and to compare with references: World Health Organization (WHO) child growth standards, and healthy Southeast Asian (SEA) infants. Further, to assess the association between growth in the first year and neurodevelopment at 2 years corrected age (CA).METHODS: We conducted a cohort study to follow up preterm infants discharged from a neonatal intensive care unit for 2 years. Weight, length and head circumference (HC) were measured at 3, 12 and 24 months CA. Neurodevelopment was assessed using Bayley Scales of Infant and Toddler Development-3rd Edition at 24 months CA.RESULTS: Over 90% of the cohort showed catch-up weight at 3 months CA. Weight and length were comparable to healthy SEA but were lower than WHO standards. HC was significantly smaller than those of WHO standards with HC Z-scores steadily decreasing from -0.95 at 3 months CA to -1.50 at 24 months CA. Each one decrement of HC Z-score from 3 to 12 months CA was associated with nearly twice an increase in odds of mental delay at 24 months CA (odds ratio 1.89; 95% confidence interval 1.02-3.50).CONCLUSION: Vietnamese preterm infants exhibited early catch-up weight but poor head growth, which was associated with later delays in mental development. Our findings support the importance of HC measures in follow-up for preterm infants.

AB - BACKGROUND: Preterm infants in low- and middle-income countries are at high risk of poor physical growth, but their growth data are still scarce.OBJECTIVES: To describe the growth of Vietnamese preterm infants in the first 2 years, and to compare with references: World Health Organization (WHO) child growth standards, and healthy Southeast Asian (SEA) infants. Further, to assess the association between growth in the first year and neurodevelopment at 2 years corrected age (CA).METHODS: We conducted a cohort study to follow up preterm infants discharged from a neonatal intensive care unit for 2 years. Weight, length and head circumference (HC) were measured at 3, 12 and 24 months CA. Neurodevelopment was assessed using Bayley Scales of Infant and Toddler Development-3rd Edition at 24 months CA.RESULTS: Over 90% of the cohort showed catch-up weight at 3 months CA. Weight and length were comparable to healthy SEA but were lower than WHO standards. HC was significantly smaller than those of WHO standards with HC Z-scores steadily decreasing from -0.95 at 3 months CA to -1.50 at 24 months CA. Each one decrement of HC Z-score from 3 to 12 months CA was associated with nearly twice an increase in odds of mental delay at 24 months CA (odds ratio 1.89; 95% confidence interval 1.02-3.50).CONCLUSION: Vietnamese preterm infants exhibited early catch-up weight but poor head growth, which was associated with later delays in mental development. Our findings support the importance of HC measures in follow-up for preterm infants.

KW - growth

KW - head circumference

KW - low-resource settings

KW - neurodevelopment

KW - preterm

KW - South East Asia

UR - http://www.scopus.com/inward/record.url?scp=85102909288&partnerID=8YFLogxK

U2 - 10.1093/tropej/fmaa117

DO - 10.1093/tropej/fmaa117

M3 - Journal article

C2 - 33346849

VL - 67

JO - Journal of Tropical Pediatrics

JF - Journal of Tropical Pediatrics

SN - 0142-6338

IS - 1

M1 - fmaa117

ER -

ID: 61594745