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Rigshospitalet - en del af Københavns Universitetshospital
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Platelet aggregation following trauma: a prospective study

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We aimed to elucidate platelet function in trauma patients, as it is pivotal for hemostasis yet remains scarcely investigated in this population. We conducted a prospective observational study of platelet aggregation capacity in 213 adult trauma patients on admission to an emergency department (ED). Inclusion criteria were trauma team activation and arterial cannula insertion on arrival. Blood samples were analyzed by multiple electrode aggregometry initiated by thrombin receptor agonist peptide 6 (TRAP) or collagen using a Multiplate device. Blood was sampled median 65 min after injury; median injury severity score (ISS) was 17; 14 (7%) patients received 10 or more units of red blood cells in the ED (massive transfusion); 24 (11%) patients died within 28 days of trauma: 17 due to cerebral injuries, four due to exsanguination, and three from other causes. No significant association was found between aggregation response and ISS. Higher TRAP values were associated with death due to cerebral injuries (P 
OriginalsprogEngelsk
TidsskriftBlood Coagulation and Fibrinolysis
Vol/bind25
Udgave nummer1
Sider (fra-til)67-73
Antal sider7
ISSN0957-5235
DOI
StatusUdgivet - 2014

ID: 39037488