Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Physical activity and muscle-brain crosstalk

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Reply to 'Paracetamol use in pregnancy - neglecting context promotes misinterpretation'

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Exerkines in health, resilience and disease

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Environmental factors in declining human fertility

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Paracetamol use during pregnancy - a call for precautionary action

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Exercise suppresses tumor growth independent of high fat food intake and associated immune dysfunction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Amino acid metabolism and protein turnover in lean and obese humans during exercise ─ effect of IL-6 receptor blockade

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Exerkines in health, resilience and disease

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Interleukin 6 as an energy allocator in muscle tissue

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Neurological and mental illnesses account for a considerable proportion of the global burden of disease. Exercise has many beneficial effects on brain health, contributing to decreased risks of dementia, depression and stress, and it has a role in restoring and maintaining cognitive function and metabolic control. The fact that exercise is sensed by the brain suggests that muscle-induced peripheral factors enable direct crosstalk between muscle and brain function. Muscle secretes myokines that contribute to the regulation of hippocampal function. Evidence is accumulating that the myokine cathepsin B passes through the blood-brain barrier to enhance brain-derived neurotrophic factor production and hence neurogenesis, memory and learning. Exercise increases neuronal gene expression of FNDC5 (which encodes the PGC1α-dependent myokine FNDC5), which can likewise contribute to increased brain-derived neurotrophic factor levels. Serum levels of the prototype myokine, IL-6, increase with exercise and might contribute to the suppression of central mechanisms of feeding. Exercise also increases the PGC1α-dependent muscular expression of kynurenine aminotransferase enzymes, which induces a beneficial shift in the balance between the neurotoxic kynurenine and the neuroprotective kynurenic acid, thereby reducing depression-like symptoms. Myokine signalling, other muscular factors and exercise-induced hepatokines and adipokines are implicated in mediating the exercise-induced beneficial impact on neurogenesis, cognitive function, appetite and metabolism, thus supporting the existence of a muscle-brain endocrine loop.

OriginalsprogEngelsk
TidsskriftNature reviews. Endocrinology
Vol/bind15
Udgave nummer7
Sider (fra-til)383-392
Antal sider10
ISSN1759-5029
DOI
StatusUdgivet - jul. 2019

ID: 59117002