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Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system

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@article{225abdb5dd0446d9b7bdebd270abfc99,
title = "Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system",
abstract = "Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation of the cranial arteries may also play a role in increasing nociception. Prostaglandin I(2) (PGI(2)) is capable of inducing a headache in healthy volunteers, a response that is likely to be mediated by the prostaglandin I(2) receptor (IP). This study investigates the functional and molecular characteristics of the IP receptor in the rat craniovascular system. In the closed cranial window model, iloprost, an IP receptor agonist, dilated the rat middle meningeal artery (MMA) (E(max)=170{\%}±16{\%}; pED(50)=6.5±0.2) but not the rat cerebral artery (CA) in vivo. The specific antagonist of the IP receptor, CAY10441, significantly blocked the iloprost-induced response dose-dependently, with the highest dose attenuating iloprost (1μgkg(-1)) induced dilatations by 70{\%} (p",
keywords = "Animals, Benzyl Compounds, Cerebral Arteries, Epoprostenol, Iloprost, Imidazoles, Male, Meningeal Arteries, Muscle, Smooth, Vascular, Nociception, Rats, Rats, Sprague-Dawley, Receptors, Epoprostenol, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Vasodilation, Vasodilator Agents",
author = "Maja Myren and Jes Olesen and Saurabh Gupta",
note = "Copyright {\circledC} 2011 Elsevier Inc. All rights reserved.",
year = "2011",
month = "7",
doi = "10.1016/j.vph.2011.06.004",
language = "English",
volume = "55",
pages = "50--8",
journal = "Vascular Pharmacology",
issn = "1537-1891",
publisher = "Elsevier Inc",
number = "1-3",

}

RIS

TY - JOUR

T1 - Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system

AU - Myren, Maja

AU - Olesen, Jes

AU - Gupta, Saurabh

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2011/7

Y1 - 2011/7

N2 - Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation of the cranial arteries may also play a role in increasing nociception. Prostaglandin I(2) (PGI(2)) is capable of inducing a headache in healthy volunteers, a response that is likely to be mediated by the prostaglandin I(2) receptor (IP). This study investigates the functional and molecular characteristics of the IP receptor in the rat craniovascular system. In the closed cranial window model, iloprost, an IP receptor agonist, dilated the rat middle meningeal artery (MMA) (E(max)=170%±16%; pED(50)=6.5±0.2) but not the rat cerebral artery (CA) in vivo. The specific antagonist of the IP receptor, CAY10441, significantly blocked the iloprost-induced response dose-dependently, with the highest dose attenuating iloprost (1μgkg(-1)) induced dilatations by 70% (p

AB - Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation of the cranial arteries may also play a role in increasing nociception. Prostaglandin I(2) (PGI(2)) is capable of inducing a headache in healthy volunteers, a response that is likely to be mediated by the prostaglandin I(2) receptor (IP). This study investigates the functional and molecular characteristics of the IP receptor in the rat craniovascular system. In the closed cranial window model, iloprost, an IP receptor agonist, dilated the rat middle meningeal artery (MMA) (E(max)=170%±16%; pED(50)=6.5±0.2) but not the rat cerebral artery (CA) in vivo. The specific antagonist of the IP receptor, CAY10441, significantly blocked the iloprost-induced response dose-dependently, with the highest dose attenuating iloprost (1μgkg(-1)) induced dilatations by 70% (p

KW - Animals

KW - Benzyl Compounds

KW - Cerebral Arteries

KW - Epoprostenol

KW - Iloprost

KW - Imidazoles

KW - Male

KW - Meningeal Arteries

KW - Muscle, Smooth, Vascular

KW - Nociception

KW - Rats

KW - Rats, Sprague-Dawley

KW - Receptors, Epoprostenol

KW - Receptors, Prostaglandin E, EP2 Subtype

KW - Receptors, Prostaglandin E, EP4 Subtype

KW - Vasodilation

KW - Vasodilator Agents

U2 - 10.1016/j.vph.2011.06.004

DO - 10.1016/j.vph.2011.06.004

M3 - Journal article

VL - 55

SP - 50

EP - 58

JO - Vascular Pharmacology

JF - Vascular Pharmacology

SN - 1537-1891

IS - 1-3

ER -

ID: 34670673