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TY - JOUR
T1 - Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system
AU - Myren, Maja
AU - Olesen, Jes
AU - Gupta, Saurabh
N1 - Copyright © 2011 Elsevier Inc. All rights reserved.
PY - 2011/7
Y1 - 2011/7
N2 - Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation of the cranial arteries may also play a role in increasing nociception. Prostaglandin I(2) (PGI(2)) is capable of inducing a headache in healthy volunteers, a response that is likely to be mediated by the prostaglandin I(2) receptor (IP). This study investigates the functional and molecular characteristics of the IP receptor in the rat craniovascular system. In the closed cranial window model, iloprost, an IP receptor agonist, dilated the rat middle meningeal artery (MMA) (E(max)=170%±16%; pED(50)=6.5±0.2) but not the rat cerebral artery (CA) in vivo. The specific antagonist of the IP receptor, CAY10441, significantly blocked the iloprost-induced response dose-dependently, with the highest dose attenuating iloprost (1μgkg(-1)) induced dilatations by 70% (p
AB - Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation of the cranial arteries may also play a role in increasing nociception. Prostaglandin I(2) (PGI(2)) is capable of inducing a headache in healthy volunteers, a response that is likely to be mediated by the prostaglandin I(2) receptor (IP). This study investigates the functional and molecular characteristics of the IP receptor in the rat craniovascular system. In the closed cranial window model, iloprost, an IP receptor agonist, dilated the rat middle meningeal artery (MMA) (E(max)=170%±16%; pED(50)=6.5±0.2) but not the rat cerebral artery (CA) in vivo. The specific antagonist of the IP receptor, CAY10441, significantly blocked the iloprost-induced response dose-dependently, with the highest dose attenuating iloprost (1μgkg(-1)) induced dilatations by 70% (p
KW - Animals
KW - Benzyl Compounds
KW - Cerebral Arteries
KW - Epoprostenol
KW - Iloprost
KW - Imidazoles
KW - Male
KW - Meningeal Arteries
KW - Muscle, Smooth, Vascular
KW - Nociception
KW - Rats
KW - Rats, Sprague-Dawley
KW - Receptors, Epoprostenol
KW - Receptors, Prostaglandin E, EP2 Subtype
KW - Receptors, Prostaglandin E, EP4 Subtype
KW - Vasodilation
KW - Vasodilator Agents
U2 - 10.1016/j.vph.2011.06.004
DO - 10.1016/j.vph.2011.06.004
M3 - Journal article
VL - 55
SP - 50
EP - 58
JO - Vascular Pharmacology
JF - Vascular Pharmacology
SN - 1537-1891
IS - 1-3
ER -
ID: 34670673