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Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system

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DOI

  1. Functional gene networks reveal distinct mechanisms segregating in migraine families

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. No central action of CGRP antagonising drugs in the GTN mouse model of migraine

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  3. Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

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  4. Letter to the editor regarding proposed new diagnostic criteria for migraine

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Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation of the cranial arteries may also play a role in increasing nociception. Prostaglandin I(2) (PGI(2)) is capable of inducing a headache in healthy volunteers, a response that is likely to be mediated by the prostaglandin I(2) receptor (IP). This study investigates the functional and molecular characteristics of the IP receptor in the rat craniovascular system. In the closed cranial window model, iloprost, an IP receptor agonist, dilated the rat middle meningeal artery (MMA) (E(max)=170%±16%; pED(50)=6.5±0.2) but not the rat cerebral artery (CA) in vivo. The specific antagonist of the IP receptor, CAY10441, significantly blocked the iloprost-induced response dose-dependently, with the highest dose attenuating iloprost (1μgkg(-1)) induced dilatations by 70% (p
OriginalsprogEngelsk
TidsskriftVascular Pharmacology
Vol/bind55
Udgave nummer1-3
Sider (fra-til)50-8
Antal sider9
ISSN1537-1891
DOI
StatusUdgivet - jul. 2011

ID: 34670673