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Persistent postoperative pain and sensory changes following lymph node excision in melanoma patients: a topical review

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Evaluation of the contribution of germline variants in BRCA1 and BRCA2 to uveal and cutaneous melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Global microRNA profiling of metastatic conjunctival melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Targeted ultrasound and fine-needle aspiration cytology for sentinel node diagnostics in early-stage melanoma: a validation study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Increased incidence of melanoma in situ in Denmark from 1997 to 2011: results from a nationwide population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Serum interleukin-6 as a prognostic biomarker in patients with metastatic melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Simultaneous quantification of high-dose naloxone and naloxone-3-β-d-glucuronide in human plasma by UHPLC-MS/MS

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Charlotte Slagelse
  • Karin Petersen
  • Jørgen B Dahl
  • Kenneth Finnerup
  • Kaitlin Greene
  • Stanley P Leong
  • Jon Levine
  • Michael Rowbotham
  • Mads Utke Werner
  • Nanna Brix Finnerup
Vis graf over relationer
Studies on complications related to chronic nerve injury following sentinel lymph node biopsy (SLNB) and complete lymph node dissection (CLND) for melanoma are sparse. This review summarizes the existing literature on pain and neuropathic complications in melanoma patients undergoing SLNB with or without CLND. The Cochrane Central Register of Controlled Trials and the Embase and PubMed databases were searched. Full-text English language articles published before June 2013 were included. Prospective and retrospective studies assessing persistent (>1 month) sensory nerve injury, postoperative pain, neuropathic pain, and sensory disturbances following SLNB with or without CLND in melanoma patients were eligible. Nine studies (six prospective and three retrospective) including data for 3632 patients met our inclusion criteria. Outcome parameters were too heterogeneous to conduct a quantitative analysis, and few studies systematically evaluated pain and sensory abnormalities. Persistent postoperative pain was reported in 1-14% of patients following SLNB and in 6-34% following CLND and sensory abnormalities in 0.1-32 and 2-82%, respectively. In the one study that assessed the type of pain, neuropathic pain was suggested to explain persistent pain in 31-66% of patients with SLNB and 82-89% of patients with CLND. Sensory-nerve-related complications in melanoma patients seem to be less pronounced following SLNB compared with CLND. Prospective observational studies are necessary to identify predictors of persistent pain, to evaluate the prevalence and impact of pain and sensory abnormalities, and to develop strategies for prevention of long-term complications.
OriginalsprogEngelsk
TidsskriftMelanoma Research
Vol/bind24
Udgave nummer2
Sider (fra-til)93-98
ISSN0960-8931
DOI
StatusUdgivet - 2014

ID: 41959569