Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Periprocedural Heparin During Endovascular Treatment of Tandem Lesions in Patients with Acute Ischemic Stroke: A Propensity Score Analysis from TITAN Registry

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Zhu, F, Piotin, M, Steglich-Arnholm, H, Labreuche, J, Holtmannspötter, M, Taschner, C, Eiden, S, Haussen, DC, Nogueira, RG, Papanagiotou, P, Boutchakova, M, Siddiqui, AH, Lapergue, B, Dorn, F, Cognard, C, Killer-Oberpfalzer, M, Mangiafico, S, Ribo, M, Psychogios, MN, Spiotta, A, Anadani, M, Labeyrie, M-A, Mazighi, M, Biondi, A, Richard, S, Anxionnat, R, Bracard, S, Turjman, F, Gory, B & TITAN (Thrombectomy In TANdem Lesions) Investigators 2019, 'Periprocedural Heparin During Endovascular Treatment of Tandem Lesions in Patients with Acute Ischemic Stroke: A Propensity Score Analysis from TITAN Registry', Cardiovascular and Interventional Radiology, bind 42, nr. 8, s. 1160-1167. https://doi.org/10.1007/s00270-019-02251-4

APA

Zhu, F., Piotin, M., Steglich-Arnholm, H., Labreuche, J., Holtmannspötter, M., Taschner, C., Eiden, S., Haussen, D. C., Nogueira, R. G., Papanagiotou, P., Boutchakova, M., Siddiqui, A. H., Lapergue, B., Dorn, F., Cognard, C., Killer-Oberpfalzer, M., Mangiafico, S., Ribo, M., Psychogios, M. N., ... TITAN (Thrombectomy In TANdem Lesions) Investigators (2019). Periprocedural Heparin During Endovascular Treatment of Tandem Lesions in Patients with Acute Ischemic Stroke: A Propensity Score Analysis from TITAN Registry. Cardiovascular and Interventional Radiology, 42(8), 1160-1167. https://doi.org/10.1007/s00270-019-02251-4

CBE

Zhu F, Piotin M, Steglich-Arnholm H, Labreuche J, Holtmannspötter M, Taschner C, Eiden S, Haussen DC, Nogueira RG, Papanagiotou P, Boutchakova M, Siddiqui AH, Lapergue B, Dorn F, Cognard C, Killer-Oberpfalzer M, Mangiafico S, Ribo M, Psychogios MN, Spiotta A, Anadani M, Labeyrie M-A, Mazighi M, Biondi A, Richard S, Anxionnat R, Bracard S, Turjman F, Gory B, TITAN (Thrombectomy In TANdem Lesions) Investigators. 2019. Periprocedural Heparin During Endovascular Treatment of Tandem Lesions in Patients with Acute Ischemic Stroke: A Propensity Score Analysis from TITAN Registry. Cardiovascular and Interventional Radiology. 42(8):1160-1167. https://doi.org/10.1007/s00270-019-02251-4

MLA

Vancouver

Author

Zhu, François ; Piotin, Michel ; Steglich-Arnholm, Henrik ; Labreuche, Julien ; Holtmannspötter, Markus ; Taschner, Christian ; Eiden, Sebastian ; Haussen, Diogo C ; Nogueira, Raul G ; Papanagiotou, Panagiotis ; Boutchakova, Maria ; Siddiqui, Adnan H ; Lapergue, Bertrand ; Dorn, Franziska ; Cognard, Christophe ; Killer-Oberpfalzer, Monika ; Mangiafico, Salvatore ; Ribo, Marc ; Psychogios, Marios N ; Spiotta, Alejandro ; Anadani, Mohammad ; Labeyrie, Marc-Antoine ; Mazighi, Mikael ; Biondi, Alessandra ; Richard, Sébastien ; Anxionnat, René ; Bracard, Serge ; Turjman, Francis ; Gory, Benjamin ; TITAN (Thrombectomy In TANdem Lesions) Investigators. / Periprocedural Heparin During Endovascular Treatment of Tandem Lesions in Patients with Acute Ischemic Stroke : A Propensity Score Analysis from TITAN Registry. I: Cardiovascular and Interventional Radiology. 2019 ; Bind 42, Nr. 8. s. 1160-1167.

Bibtex

@article{38df23966187464599b8501698f83a6c,
title = "Periprocedural Heparin During Endovascular Treatment of Tandem Lesions in Patients with Acute Ischemic Stroke: A Propensity Score Analysis from TITAN Registry",
abstract = "BACKGROUND AND PURPOSE: Data on safety and efficacy of periprocedural use of heparin are limited during treatment of acute ischemic stroke patients with anterior circulation tandem occlusion. This study aimed to investigate the impact of heparin use during endovascular therapy of anterior circulation tandem occlusions on the functional and safety outcomes.METHODS: A retrospective analysis of the multicenter observational TITAN registry was performed. Patients with anterior circulation tandem occlusion and treated with endovascular therapy (EVT) were included, with or without extracranial carotid intervention. We divided patients into two groups based on periprocedural heparin use (heparin vs. non-heparin). The dose of intravenous unfractionated heparin ranged from 1500 to 2500 I.U. Primary study endpoint was 90-day Modified Rankin Scale (mRS). Secondary study endpoint included angiographic and safety endpoints such as hemorrhagic complications. A propensity-score-matched analysis was performed.RESULTS: Among 369 patients, heparin was used in 68 patients (18.4%). In the propensity-score-matched cohort, favorable outcome (mRS 0-2) occurred in 51.3% in heparin group and 58.0% in non-heparin group (matched OR, 0.76; 95% CI, 0.32-1.78; P = 0.52). Similar result was found in propensity-score-adjusted cohort (adjusted OR, 0.72; 95%CI, 0.39-1.32; P = 0.28). Likewise, there was no difference in the rate of successful reperfusion (mTICI 2b-3) (propensity-score-adjusted OR, 1.03; 95%CI, 0.50-2.09; P = 0.93) neither in safety endpoints between the two groups.CONCLUSIONS: Periprocedural heparin use during EVT of anterior circulation tandem occlusions was not associated with better functional, angiographic or safety outcomes. These findings are applicable for low doses of heparin, and further studies are warranted.",
keywords = "Anticoagulation, Endovascular Treatment, Heparin, Stroke, Tandem occlusion, Thrombectomy",
author = "Fran{\c c}ois Zhu and Michel Piotin and Henrik Steglich-Arnholm and Julien Labreuche and Markus Holtmannsp{\"o}tter and Christian Taschner and Sebastian Eiden and Haussen, {Diogo C} and Nogueira, {Raul G} and Panagiotis Papanagiotou and Maria Boutchakova and Siddiqui, {Adnan H} and Bertrand Lapergue and Franziska Dorn and Christophe Cognard and Monika Killer-Oberpfalzer and Salvatore Mangiafico and Marc Ribo and Psychogios, {Marios N} and Alejandro Spiotta and Mohammad Anadani and Marc-Antoine Labeyrie and Mikael Mazighi and Alessandra Biondi and S{\'e}bastien Richard and Ren{\'e} Anxionnat and Serge Bracard and Francis Turjman and Benjamin Gory and {TITAN (Thrombectomy In TANdem Lesions) Investigators}",
year = "2019",
month = aug,
day = "15",
doi = "10.1007/s00270-019-02251-4",
language = "English",
volume = "42",
pages = "1160--1167",
journal = "Cardiovascular and Interventional Radiology",
issn = "0174-1551",
publisher = "Springer New York LLC",
number = "8",

}

RIS

TY - JOUR

T1 - Periprocedural Heparin During Endovascular Treatment of Tandem Lesions in Patients with Acute Ischemic Stroke

T2 - A Propensity Score Analysis from TITAN Registry

AU - Zhu, François

AU - Piotin, Michel

AU - Steglich-Arnholm, Henrik

AU - Labreuche, Julien

AU - Holtmannspötter, Markus

AU - Taschner, Christian

AU - Eiden, Sebastian

AU - Haussen, Diogo C

AU - Nogueira, Raul G

AU - Papanagiotou, Panagiotis

AU - Boutchakova, Maria

AU - Siddiqui, Adnan H

AU - Lapergue, Bertrand

AU - Dorn, Franziska

AU - Cognard, Christophe

AU - Killer-Oberpfalzer, Monika

AU - Mangiafico, Salvatore

AU - Ribo, Marc

AU - Psychogios, Marios N

AU - Spiotta, Alejandro

AU - Anadani, Mohammad

AU - Labeyrie, Marc-Antoine

AU - Mazighi, Mikael

AU - Biondi, Alessandra

AU - Richard, Sébastien

AU - Anxionnat, René

AU - Bracard, Serge

AU - Turjman, Francis

AU - Gory, Benjamin

AU - TITAN (Thrombectomy In TANdem Lesions) Investigators

PY - 2019/8/15

Y1 - 2019/8/15

N2 - BACKGROUND AND PURPOSE: Data on safety and efficacy of periprocedural use of heparin are limited during treatment of acute ischemic stroke patients with anterior circulation tandem occlusion. This study aimed to investigate the impact of heparin use during endovascular therapy of anterior circulation tandem occlusions on the functional and safety outcomes.METHODS: A retrospective analysis of the multicenter observational TITAN registry was performed. Patients with anterior circulation tandem occlusion and treated with endovascular therapy (EVT) were included, with or without extracranial carotid intervention. We divided patients into two groups based on periprocedural heparin use (heparin vs. non-heparin). The dose of intravenous unfractionated heparin ranged from 1500 to 2500 I.U. Primary study endpoint was 90-day Modified Rankin Scale (mRS). Secondary study endpoint included angiographic and safety endpoints such as hemorrhagic complications. A propensity-score-matched analysis was performed.RESULTS: Among 369 patients, heparin was used in 68 patients (18.4%). In the propensity-score-matched cohort, favorable outcome (mRS 0-2) occurred in 51.3% in heparin group and 58.0% in non-heparin group (matched OR, 0.76; 95% CI, 0.32-1.78; P = 0.52). Similar result was found in propensity-score-adjusted cohort (adjusted OR, 0.72; 95%CI, 0.39-1.32; P = 0.28). Likewise, there was no difference in the rate of successful reperfusion (mTICI 2b-3) (propensity-score-adjusted OR, 1.03; 95%CI, 0.50-2.09; P = 0.93) neither in safety endpoints between the two groups.CONCLUSIONS: Periprocedural heparin use during EVT of anterior circulation tandem occlusions was not associated with better functional, angiographic or safety outcomes. These findings are applicable for low doses of heparin, and further studies are warranted.

AB - BACKGROUND AND PURPOSE: Data on safety and efficacy of periprocedural use of heparin are limited during treatment of acute ischemic stroke patients with anterior circulation tandem occlusion. This study aimed to investigate the impact of heparin use during endovascular therapy of anterior circulation tandem occlusions on the functional and safety outcomes.METHODS: A retrospective analysis of the multicenter observational TITAN registry was performed. Patients with anterior circulation tandem occlusion and treated with endovascular therapy (EVT) were included, with or without extracranial carotid intervention. We divided patients into two groups based on periprocedural heparin use (heparin vs. non-heparin). The dose of intravenous unfractionated heparin ranged from 1500 to 2500 I.U. Primary study endpoint was 90-day Modified Rankin Scale (mRS). Secondary study endpoint included angiographic and safety endpoints such as hemorrhagic complications. A propensity-score-matched analysis was performed.RESULTS: Among 369 patients, heparin was used in 68 patients (18.4%). In the propensity-score-matched cohort, favorable outcome (mRS 0-2) occurred in 51.3% in heparin group and 58.0% in non-heparin group (matched OR, 0.76; 95% CI, 0.32-1.78; P = 0.52). Similar result was found in propensity-score-adjusted cohort (adjusted OR, 0.72; 95%CI, 0.39-1.32; P = 0.28). Likewise, there was no difference in the rate of successful reperfusion (mTICI 2b-3) (propensity-score-adjusted OR, 1.03; 95%CI, 0.50-2.09; P = 0.93) neither in safety endpoints between the two groups.CONCLUSIONS: Periprocedural heparin use during EVT of anterior circulation tandem occlusions was not associated with better functional, angiographic or safety outcomes. These findings are applicable for low doses of heparin, and further studies are warranted.

KW - Anticoagulation

KW - Endovascular Treatment

KW - Heparin

KW - Stroke

KW - Tandem occlusion

KW - Thrombectomy

UR - http://www.scopus.com/inward/record.url?scp=85066467531&partnerID=8YFLogxK

U2 - 10.1007/s00270-019-02251-4

DO - 10.1007/s00270-019-02251-4

M3 - Journal article

C2 - 31152229

VL - 42

SP - 1160

EP - 1167

JO - Cardiovascular and Interventional Radiology

JF - Cardiovascular and Interventional Radiology

SN - 0174-1551

IS - 8

ER -

ID: 58224638