Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Peripheral intravascular lithotripsy for transcatheter aortic valve implantation: a multicentre observational study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Percutaneous left atrial appendage closure in a surgically ligated left atrial appendage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Computed Tomography-Based Selection of Transseptal Puncture Site for Percutaneous Left Atrial Appendage Closure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cusp overlap technique during Valve-in-Valve TAVI using the novel Navitor transcatheter heart valve

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Membranous septum morphology predicting the risk of conduction abnormalities after transcatheter aortic valve implantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Does Subclinical Leaflet Thrombosis Impact the Durability of Bioprosthetic Aortic Valves?

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  2. Percutaneous left atrial appendage closure in a surgically ligated left atrial appendage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Mitral Valve Infective Endocarditis after Trans-Catheter Aortic Valve Implantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Giulia Nardi
  • Ole De Backer
  • Francesco Saia
  • Lars Søndergaard
  • Francesca Ristalli
  • Francesco Meucci
  • Miroslava Stolcova
  • Alessio Mattesini
  • Pierluigi Demola
  • Xi Wang
  • Anees Al Jabri
  • Tullio Palmerini
  • Antonio Giulio Bruno
  • Alfonso Ielasi
  • Eric Van Belle
  • Sergio Berti
  • Carlo Di Mario
Vis graf over relationer

BACKGROUND: The presence of severe calcific atherosclerosis at the iliofemoral axis may preclude transcatheter aortic valve implantation (TAVI) by the transfemoral (TF) approach. Intravascular lithotripsy (IVL) is a novel technology that fractures intimal/medial calcium and increases vessel compliance allowing TF TAVI in selected patients with peripheral artery disease (PAD).

AIMS: The aim of this study was to report on the safety and efficacy of IVL-assisted TF TAVI in an all-comers population.

METHODS: Clinical, imaging and procedural data on all consecutive patients treated by IVL-assisted TF TAVI in six high-volume European centres (2018-2020) were collected in this prospective, real-world, multicentre registry.

RESULTS: IVL-assisted TF TAVI was performed in 108 patients, increasing from 2.4% to 6.5% of all TAVI from 2018 to 2020, respectively. The target lesion was most often localised at the common and/or external iliac artery (93.5% of cases; average TL-MLD 4.6±0.9 mm with 318 degrees of calcium arc). Transfemoral aortic valve delivery was successful in 100% of cases; final procedural success in 98.2% (two conversions to cardiac open surgery for annular rupture and valve migration). Complications of the IVL-treated segments consisted of 1 perforation and 3 major dissections requiring stent implantation (2 covered stents and 2 BMS). Access-site-related complications included 3 major bleedings. Three in-hospital deaths were recorded (2.8%, 1 failed surgical conversion after annular rupture, 1 cardiac arrest after initial valvuloplasty, 1 late hyperkalaemia in renal dysfunction).

CONCLUSIONS: IVL-assisted TF TAVI proved to be a safe and effective approach, which helps to expand the indications for TF TAVI in patients with severe calcific PAD. However, these patients continue to have a higher-than-average incidence of periprocedural complications.

OriginalsprogEngelsk
TidsskriftEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Vol/bind17
Udgave nummer17
Sider (fra-til)e1397-e1406
ISSN1774-024X
DOI
StatusUdgivet - 1 apr. 2022

ID: 72637378