Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. 2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. EULAR recommendations for the reporting of ultrasound studies in rheumatic and musculoskeletal diseases (RMDs)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Axial involvement in patients with early peripheral spondyloarthritis: a prospective MRI study of sacroiliac joints and spine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Early life body size, growth and risks of systemic lupus erythematosus - A large Danish observational cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hydroxychloroquine in patients with rheumatic diseases during the COVID-19 pandemic: a letter to clinicians

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  3. Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Sindhu R Johnson
  • Ralph Brinks
  • Karen H Costenbader
  • David Daikh
  • Marta Mosca
  • Rosalind Ramsey-Goldman
  • Josef S Smolen
  • David Wofsy
  • Dimitrios T Boumpas
  • Diane L Kamen
  • David Jayne
  • R Cervera
  • Nathalie Costedoat-Chalumeau
  • Betty Diamond
  • Dafna D Gladman
  • Bevra Hahn
  • Falk Hiepe
  • Søren Jacobsen
  • Dinesh Khanna
  • Kirsten Lerstrøm
  • Elena Massarotti
  • Joseph McCune
  • Guillermo Ruiz-Irastorza
  • Jorge Sanchez-Guerrero
  • Matthias Schneider
  • Murray Urowitz
  • George Bertsias
  • Bimba F Hoyer
  • Nicolai Leuchten
  • Chiara Tani
  • Sara K Tedeschi
  • Zahi Touma
  • Gabriela Schmajuk
  • Branimir Anic
  • Florence Assan
  • Tak Mao Chan
  • Ann Elaine Clarke
  • Mary K Crow
  • László Czirják
  • Andrea Doria
  • Winfried B Graninger
  • Bernadett Halda-Kiss
  • Sarfaraz Hasni
  • Peter M Izmirly
  • Michelle Jung
  • Gábor Kumánovics
  • Xavier Mariette
  • Ivan Padjen
  • José M Pego-Reigosa
  • Juanita Romero-Diaz
  • Íñigo Rúa-Figueroa
  • Raphaèle Seror
  • Georg H Stummvoll
  • Yoshiya Tanaka
  • Maria G Tektonidou
  • Carlos Vasconcelos
  • Edward M Vital
  • D J Wallace
  • Sule Yavuz
  • Pier Luigi Meroni
  • Marvin J Fritzler
  • Ray Naden
  • Thomas Dörner
  • Martin Aringer
Vis graf over relationer

OBJECTIVES: The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 Classification Criteria for systemic lupus erythematosus (SLE) have been validated with high sensitivity and specificity. We evaluated the performance of the new criteria with regard to disease duration, sex and race/ethnicity, and compared its performance against the Systemic Lupus International Collaborating Clinics (SLICC) 2012 and ACR 1982/1997 criteria.

METHODS: Twenty-one SLE centres from 16 countries submitted SLE cases and mimicking controls to form the validation cohort. The sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated.

RESULTS: The cohort consisted of female (n=1098), male (n=172), Asian (n=118), black (n=68), Hispanic (n=124) and white (n=941) patients; with an SLE duration of 1 to <3 years (n=196) and ≥5 years (n=879). Among patients with 1 to <3 years disease duration, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 81%). The EULAR/ACR criteria performed well in men (sensitivity 93%, specificity 96%) and women (sensitivity 97%, specificity 94%). Among women, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 83%) and better specificity than the SLICC criteria (94% vs 82%). Among white patients, the EULAR/ACR criteria had better sensitivity than the ACR criteria (95% vs 83%) and better specificity than the SLICC criteria (94% vs 83%). The EULAR/ACR criteria performed well among black patients (sensitivity of 98%, specificity 100%), and had better sensitivity than the ACR criteria among Hispanic patients (100% vs 86%) and Asian patients (97% vs 77%).

CONCLUSIONS: The EULAR/ACR 2019 criteria perform well among patients with early disease, men, women, white, black, Hispanic and Asian patients. These criteria have superior sensitivity than the ACR criteria and/or superior specificity than the SLICC criteria across many subgroups.

OriginalsprogEngelsk
TidsskriftAnnals of the Rheumatic Diseases
Vol/bind79
Udgave nummer10
Sider (fra-til)1333-1339
Antal sider7
ISSN0003-4967
DOI
StatusUdgivet - okt. 2020

Bibliografisk note

© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

ID: 61878128