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Patient characteristics of olfactory neuroblastoma: experience from a tertiary cancer centre 2000-2016 covering Eastern Denmark

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@article{1f556a7b848d435181c6438a61b84671,
title = "Patient characteristics of olfactory neuroblastoma: experience from a tertiary cancer centre 2000-2016 covering Eastern Denmark",
abstract = "The aim of this study was to report incidence and patient characteristics of olfactory neuroblastoma (ONB) at a tertiary cancer institution during a 16-year period. A retrospective review was conducted on patients with ONB treated at Rigshospitalet, Copenhagen from 2000 to 2016 covering Eastern Denmark. Patient demographics, symptoms, stage, pathology-reports, treatment, and outcome were extracted from the patient records and the Danish pathology register. The tumours were graded both histologically and clinically using Hyam's and Kadish classifications, respectively. We identified a total of 14 patients (ten males, four females, median age 57 years, range 17-81 years). Four patients were in Kadish stage A, one stage B, and seven stage C. According to Hyam's classification, two tumours were grade I, nine grade II, and three grade III. All patients were treated with surgery, eight in combination with radiotherapy, where one received proton therapy, and one a combination with chemotherapy. At a median follow-up time of 58 months, the 5-year overall survival was 90{\%} (95{\%} CI 61; 99). ONB is a rare disease; complete radical surgery alone or combined with radiotherapy offered good oncologic control and outcome. Long-term follow-up of ONB should be mandatory.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Denmark, Esthesioneuroblastoma, Olfactory/mortality, Female, Gamma Rays/therapeutic use, Hospitals, University, Humans, Male, Middle Aged, Nasal Cavity/drug effects, Neoplasm Grading, Neoplasm Staging, Nose Neoplasms/mortality, Prognosis, Registries, Retrospective Studies, Survival Analysis",
author = "Gram, {Signe Buhl} and Christian Gr{\o}nh{\o}j and Henriette Mann and Jakobsen, {Kathrine Kronberg} and Katalin Kiss and Anders Bilde and {von Buchwald}, Christian",
note = "{\circledC} 2018 APMIS. Published by John Wiley & Sons Ltd.",
year = "2018",
month = "8",
doi = "10.1111/apm.12859",
language = "English",
volume = "126",
pages = "663--666",
journal = "APMIS - Journal of Pathology, Microbiology and Immunology",
issn = "0903-4641",
publisher = "Wiley Online",
number = "8",

}

RIS

TY - JOUR

T1 - Patient characteristics of olfactory neuroblastoma

T2 - experience from a tertiary cancer centre 2000-2016 covering Eastern Denmark

AU - Gram, Signe Buhl

AU - Grønhøj, Christian

AU - Mann, Henriette

AU - Jakobsen, Kathrine Kronberg

AU - Kiss, Katalin

AU - Bilde, Anders

AU - von Buchwald, Christian

N1 - © 2018 APMIS. Published by John Wiley & Sons Ltd.

PY - 2018/8

Y1 - 2018/8

N2 - The aim of this study was to report incidence and patient characteristics of olfactory neuroblastoma (ONB) at a tertiary cancer institution during a 16-year period. A retrospective review was conducted on patients with ONB treated at Rigshospitalet, Copenhagen from 2000 to 2016 covering Eastern Denmark. Patient demographics, symptoms, stage, pathology-reports, treatment, and outcome were extracted from the patient records and the Danish pathology register. The tumours were graded both histologically and clinically using Hyam's and Kadish classifications, respectively. We identified a total of 14 patients (ten males, four females, median age 57 years, range 17-81 years). Four patients were in Kadish stage A, one stage B, and seven stage C. According to Hyam's classification, two tumours were grade I, nine grade II, and three grade III. All patients were treated with surgery, eight in combination with radiotherapy, where one received proton therapy, and one a combination with chemotherapy. At a median follow-up time of 58 months, the 5-year overall survival was 90% (95% CI 61; 99). ONB is a rare disease; complete radical surgery alone or combined with radiotherapy offered good oncologic control and outcome. Long-term follow-up of ONB should be mandatory.

AB - The aim of this study was to report incidence and patient characteristics of olfactory neuroblastoma (ONB) at a tertiary cancer institution during a 16-year period. A retrospective review was conducted on patients with ONB treated at Rigshospitalet, Copenhagen from 2000 to 2016 covering Eastern Denmark. Patient demographics, symptoms, stage, pathology-reports, treatment, and outcome were extracted from the patient records and the Danish pathology register. The tumours were graded both histologically and clinically using Hyam's and Kadish classifications, respectively. We identified a total of 14 patients (ten males, four females, median age 57 years, range 17-81 years). Four patients were in Kadish stage A, one stage B, and seven stage C. According to Hyam's classification, two tumours were grade I, nine grade II, and three grade III. All patients were treated with surgery, eight in combination with radiotherapy, where one received proton therapy, and one a combination with chemotherapy. At a median follow-up time of 58 months, the 5-year overall survival was 90% (95% CI 61; 99). ONB is a rare disease; complete radical surgery alone or combined with radiotherapy offered good oncologic control and outcome. Long-term follow-up of ONB should be mandatory.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use

KW - Denmark

KW - Esthesioneuroblastoma, Olfactory/mortality

KW - Female

KW - Gamma Rays/therapeutic use

KW - Hospitals, University

KW - Humans

KW - Male

KW - Middle Aged

KW - Nasal Cavity/drug effects

KW - Neoplasm Grading

KW - Neoplasm Staging

KW - Nose Neoplasms/mortality

KW - Prognosis

KW - Registries

KW - Retrospective Studies

KW - Survival Analysis

U2 - 10.1111/apm.12859

DO - 10.1111/apm.12859

M3 - Journal article

VL - 126

SP - 663

EP - 666

JO - APMIS - Journal of Pathology, Microbiology and Immunology

JF - APMIS - Journal of Pathology, Microbiology and Immunology

SN - 0903-4641

IS - 8

ER -

ID: 56645607