Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Paracetamol use during pregnancy - a call for precautionary action

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Reply to 'Lactate as a major myokine and exerkine'

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Reply to 'Paracetamol use in pregnancy - neglecting context promotes misinterpretation'

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  3. Exerkines in health, resilience and disease

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Environmental factors in declining human fertility

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Optimized detection of germ cell neoplasia in situ in contralateral biopsy reduces the risk of second testis cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Transorbital sonography: A non-invasive bedside screening tool for detection of pseudotumor cerebri syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA and EMA, have long considered APAP appropriate for use during pregnancy when used as directed. However, increasing experimental and epidemiological research suggests that prenatal exposure to APAP might alter fetal development, which could increase the risks of some neurodevelopmental, reproductive and urogenital disorders. Here we summarize this evidence and call for precautionary action through a focused research effort and by increasing awareness among health professionals and pregnant women. APAP is an important medication and alternatives for treatment of high fever and severe pain are limited. We recommend that pregnant women should be cautioned at the beginning of pregnancy to: forego APAP unless its use is medically indicated; consult with a physician or pharmacist if they are uncertain whether use is indicated and before using on a long-term basis; and minimize exposure by using the lowest effective dose for the shortest possible time. We suggest specific actions to implement these recommendations. This Consensus Statement reflects our concerns and is currently supported by 91 scientists, clinicians and public health professionals from across the globe.

OriginalsprogEngelsk
TidsskriftNature reviews. Endocrinology
Vol/bind17
Udgave nummer12
Sider (fra-til)757-766
Antal sider10
ISSN1759-5029
DOI
StatusUdgivet - dec. 2021

Bibliografisk note

© 2021. The Author(s).

ID: 67850509