Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Papillary thyroid microcarcinoma in denmark 1996-2008: a national study of epidemiology and clinical significance

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Londero, SC, Krogdahl, A, Bastholt, L, Overgaard, J, Trolle, W, Pedersen, HB, Bentzen, J, Schytte, S, Christiansen, PM & Godballe For The Danish Thyroid Cancer Group, C 2013, 'Papillary thyroid microcarcinoma in denmark 1996-2008: a national study of epidemiology and clinical significance', Thyroid : official journal of the American Thyroid Association, bind 23, nr. 9, s. 1159-64. https://doi.org/10.1089/thy.2012.0595

APA

Londero, S. C., Krogdahl, A., Bastholt, L., Overgaard, J., Trolle, W., Pedersen, H. B., Bentzen, J., Schytte, S., Christiansen, P. M., & Godballe For The Danish Thyroid Cancer Group, C. (2013). Papillary thyroid microcarcinoma in denmark 1996-2008: a national study of epidemiology and clinical significance. Thyroid : official journal of the American Thyroid Association, 23(9), 1159-64. https://doi.org/10.1089/thy.2012.0595

CBE

Londero SC, Krogdahl A, Bastholt L, Overgaard J, Trolle W, Pedersen HB, Bentzen J, Schytte S, Christiansen PM, Godballe For The Danish Thyroid Cancer Group C. 2013. Papillary thyroid microcarcinoma in denmark 1996-2008: a national study of epidemiology and clinical significance. Thyroid : official journal of the American Thyroid Association. 23(9):1159-64. https://doi.org/10.1089/thy.2012.0595

MLA

Vancouver

Author

Londero, Stefano Christian ; Krogdahl, Annelise ; Bastholt, Lars ; Overgaard, Jens ; Trolle, Waldemar ; Pedersen, Henrik Baymler ; Bentzen, Jens ; Schytte, Sten ; Christiansen, Peer Michael ; Godballe For The Danish Thyroid Cancer Group, Christian. / Papillary thyroid microcarcinoma in denmark 1996-2008 : a national study of epidemiology and clinical significance. I: Thyroid : official journal of the American Thyroid Association. 2013 ; Bind 23, Nr. 9. s. 1159-64.

Bibtex

@article{3e06625e804f449ea4ecce0ecf3d66b7,
title = "Papillary thyroid microcarcinoma in denmark 1996-2008: a national study of epidemiology and clinical significance",
abstract = "Background: With an observed general rise in papillary thyroid carcinoma incidence, papillary microcarcinoma (PMC) is accordingly found more frequently and often incidentally by histological examination of surgical specimens from presumed benign thyroid disease. Only a few studies have specifically addressed the prognosis of incidentally found PMC, and they have been limited to retrospective single-center studies. Methods: This was a national, unselected, prospective cohort study of 406 papillary thyroid microcarcinoma patients diagnosed in Denmark from 1996 to 2008. Objective: The aim of this study was to evaluate incidence, outcome, and extent of necessary treatment, with special attention given to incidentally detected PMC. Results: Age-standardized ratios were found to increase from 0.35 per 100,000 per year in 1996 to 0.74 per 100,000 per year in 2008. A total of 240 out of 406 cases were found incidentally, and a significant rise in incidence was only found for the incidental cases. Median follow-up was 7.6 years for the incidental cases, and in this time span, five cases of recurrence and no deaths from thyroid cancer occurred. The five-year recurrence-free survival was 98.1%, and only occurrence of lymph-node metastasis was found to affect the recurrence rate. A total of 160 incidental cases were initially treated with lobectomy, and the incidence of recurrence was not significantly different in the cases receiving completion thyroidectomy. Conclusion: The rising incidence of PMC in Denmark is explained by incidental cases. When the carcinoma is not the index tumor for surgery, this study implies that completion thyroidectomy does not improve prognosis.",
author = "Londero, {Stefano Christian} and Annelise Krogdahl and Lars Bastholt and Jens Overgaard and Waldemar Trolle and Pedersen, {Henrik Baymler} and Jens Bentzen and Sten Schytte and Christiansen, {Peer Michael} and {Godballe For The Danish Thyroid Cancer Group}, Christian",
year = "2013",
month = sep,
doi = "10.1089/thy.2012.0595",
language = "English",
volume = "23",
pages = "1159--64",
journal = "Thyroid",
issn = "1050-7256",
publisher = "Mary Ann/Liebert, Inc. Publishers",
number = "9",

}

RIS

TY - JOUR

T1 - Papillary thyroid microcarcinoma in denmark 1996-2008

T2 - a national study of epidemiology and clinical significance

AU - Londero, Stefano Christian

AU - Krogdahl, Annelise

AU - Bastholt, Lars

AU - Overgaard, Jens

AU - Trolle, Waldemar

AU - Pedersen, Henrik Baymler

AU - Bentzen, Jens

AU - Schytte, Sten

AU - Christiansen, Peer Michael

AU - Godballe For The Danish Thyroid Cancer Group, Christian

PY - 2013/9

Y1 - 2013/9

N2 - Background: With an observed general rise in papillary thyroid carcinoma incidence, papillary microcarcinoma (PMC) is accordingly found more frequently and often incidentally by histological examination of surgical specimens from presumed benign thyroid disease. Only a few studies have specifically addressed the prognosis of incidentally found PMC, and they have been limited to retrospective single-center studies. Methods: This was a national, unselected, prospective cohort study of 406 papillary thyroid microcarcinoma patients diagnosed in Denmark from 1996 to 2008. Objective: The aim of this study was to evaluate incidence, outcome, and extent of necessary treatment, with special attention given to incidentally detected PMC. Results: Age-standardized ratios were found to increase from 0.35 per 100,000 per year in 1996 to 0.74 per 100,000 per year in 2008. A total of 240 out of 406 cases were found incidentally, and a significant rise in incidence was only found for the incidental cases. Median follow-up was 7.6 years for the incidental cases, and in this time span, five cases of recurrence and no deaths from thyroid cancer occurred. The five-year recurrence-free survival was 98.1%, and only occurrence of lymph-node metastasis was found to affect the recurrence rate. A total of 160 incidental cases were initially treated with lobectomy, and the incidence of recurrence was not significantly different in the cases receiving completion thyroidectomy. Conclusion: The rising incidence of PMC in Denmark is explained by incidental cases. When the carcinoma is not the index tumor for surgery, this study implies that completion thyroidectomy does not improve prognosis.

AB - Background: With an observed general rise in papillary thyroid carcinoma incidence, papillary microcarcinoma (PMC) is accordingly found more frequently and often incidentally by histological examination of surgical specimens from presumed benign thyroid disease. Only a few studies have specifically addressed the prognosis of incidentally found PMC, and they have been limited to retrospective single-center studies. Methods: This was a national, unselected, prospective cohort study of 406 papillary thyroid microcarcinoma patients diagnosed in Denmark from 1996 to 2008. Objective: The aim of this study was to evaluate incidence, outcome, and extent of necessary treatment, with special attention given to incidentally detected PMC. Results: Age-standardized ratios were found to increase from 0.35 per 100,000 per year in 1996 to 0.74 per 100,000 per year in 2008. A total of 240 out of 406 cases were found incidentally, and a significant rise in incidence was only found for the incidental cases. Median follow-up was 7.6 years for the incidental cases, and in this time span, five cases of recurrence and no deaths from thyroid cancer occurred. The five-year recurrence-free survival was 98.1%, and only occurrence of lymph-node metastasis was found to affect the recurrence rate. A total of 160 incidental cases were initially treated with lobectomy, and the incidence of recurrence was not significantly different in the cases receiving completion thyroidectomy. Conclusion: The rising incidence of PMC in Denmark is explained by incidental cases. When the carcinoma is not the index tumor for surgery, this study implies that completion thyroidectomy does not improve prognosis.

U2 - 10.1089/thy.2012.0595

DO - 10.1089/thy.2012.0595

M3 - Journal article

C2 - 23427917

VL - 23

SP - 1159

EP - 1164

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - 9

ER -

ID: 39736009