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Papillary thyroid carcinoma in Denmark, 1996-2008: outcome and evaluation of established prognostic scoring systems in a prospective national cohort

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Harvard

Londero, SC, Krogdahl, A, Bastholt, L, Overgaard, J, Pedersen, HB, Hahn, CH, Bentzen, J, Schytte, S, Christiansen, P, Gerke, O, Godballe, C & Danish Thyroid Cancer Group-DATHYRCA (part of the DAHANCA organization)(Birte Nygaard, Peter Oturai, members) 2015, 'Papillary thyroid carcinoma in Denmark, 1996-2008: outcome and evaluation of established prognostic scoring systems in a prospective national cohort', Thyroid : official journal of the American Thyroid Association, bind 25, nr. 1, s. 78-84. https://doi.org/10.1089/thy.2014.0294

APA

Londero, S. C., Krogdahl, A., Bastholt, L., Overgaard, J., Pedersen, H. B., Hahn, C. H., Bentzen, J., Schytte, S., Christiansen, P., Gerke, O., Godballe, C., & Danish Thyroid Cancer Group-DATHYRCA (part of the DAHANCA organization)(Birte Nygaard, Peter Oturai, members) (2015). Papillary thyroid carcinoma in Denmark, 1996-2008: outcome and evaluation of established prognostic scoring systems in a prospective national cohort. Thyroid : official journal of the American Thyroid Association, 25(1), 78-84. https://doi.org/10.1089/thy.2014.0294

CBE

Londero SC, Krogdahl A, Bastholt L, Overgaard J, Pedersen HB, Hahn CH, Bentzen J, Schytte S, Christiansen P, Gerke O, Godballe C, Danish Thyroid Cancer Group-DATHYRCA (part of the DAHANCA organization)(Birte Nygaard, Peter Oturai, members). 2015. Papillary thyroid carcinoma in Denmark, 1996-2008: outcome and evaluation of established prognostic scoring systems in a prospective national cohort. Thyroid : official journal of the American Thyroid Association. 25(1):78-84. https://doi.org/10.1089/thy.2014.0294

MLA

Vancouver

Author

Londero, Stefano Christian ; Krogdahl, Annelise ; Bastholt, Lars ; Overgaard, Jens ; Pedersen, Henrik Baymler ; Hahn, Christoffer Holst ; Bentzen, Jens ; Schytte, Sten ; Christiansen, Peer ; Gerke, Oke ; Godballe, Christian ; Danish Thyroid Cancer Group-DATHYRCA (part of the DAHANCA organization)(Birte Nygaard, Peter Oturai, members). / Papillary thyroid carcinoma in Denmark, 1996-2008 : outcome and evaluation of established prognostic scoring systems in a prospective national cohort. I: Thyroid : official journal of the American Thyroid Association. 2015 ; Bind 25, Nr. 1. s. 78-84.

Bibtex

@article{e79290a6ec224bb9b976ab17ec1d162f,
title = "Papillary thyroid carcinoma in Denmark, 1996-2008: outcome and evaluation of established prognostic scoring systems in a prospective national cohort",
abstract = "BACKGROUND: Regional as well as national series show an increasing incidence of thyroid cancer largely small size papillary thyroid carcinoma (PTC). Prognostic scoring systems have been developed, but these do not take into account the rapidly changing case mix, and adjustments may be required. The purposes of this study were to evaluate treatment outcomes and to analyze the value of older prognostic scoring systems tested on a relatively new, unselected national cohort of PTC patients.METHODS: This was a national prospective cohort study conducted in Denmark, which has a population of 5.5 million.RESULTS: A total of 1350 patients were diagnosed with PTC during 1996-2008, and the median follow-up time was 7.9 years. The 10-year recurrence-free survival rate was 90.2%, and the 10-year crude and cause-specific survival (CSS) rates were 83.7% and 93.8% respectively. By multivariate Cox regression, it was possible to confirm age, metastases (distant and nodal), extrathyroidal extension, and tumor size as predictors of mortality, whereas only nodal metastases, extrathyroidal extension, and tumor size were predictors of recurrence. In analyses of older prognostic scoring systems, a significant correlation between the risk group ranks was found for survival as well as recurrence. The c-index for CSS was highest for MACIS (0.92) and lowest for AMES (0.80). In the TNM, MACIS, and EORTC systems, most patients were classified as stage 1, and for these patients, the 10-year CSS rate was approximately 99.5%, confirming the generally excellent survival.CONCLUSION: This national study provides further evidence that a favorable prognosis is to be expected for patients diagnosed with PTC. Also, it was possible to confirm age, metastases, extrathyroidal extension, and tumor size as predictors of mortality, whereas only nodal metastases, extrathyroidal extension, and tumor size were predictors of recurrence. All the scoring systems evaluated were able to produce a highly significant risk group stratification, showing that in spite of the changes in the case mix of PTC, these systems are still applicable, and in fact contain valuable prognostic information useable for treatment planning.",
author = "Londero, {Stefano Christian} and Annelise Krogdahl and Lars Bastholt and Jens Overgaard and Pedersen, {Henrik Baymler} and Hahn, {Christoffer Holst} and Jens Bentzen and Sten Schytte and Peer Christiansen and Oke Gerke and Christian Godballe and {Danish Thyroid Cancer Group-DATHYRCA (part of the DAHANCA organization)(Birte Nygaard, Peter Oturai, members)} and Birte Nygaard and Oturai, {Peter Sandor}",
year = "2015",
month = jan,
doi = "10.1089/thy.2014.0294",
language = "English",
volume = "25",
pages = "78--84",
journal = "Thyroid",
issn = "1050-7256",
publisher = "Mary Ann/Liebert, Inc. Publishers",
number = "1",

}

RIS

TY - JOUR

T1 - Papillary thyroid carcinoma in Denmark, 1996-2008

T2 - outcome and evaluation of established prognostic scoring systems in a prospective national cohort

AU - Londero, Stefano Christian

AU - Krogdahl, Annelise

AU - Bastholt, Lars

AU - Overgaard, Jens

AU - Pedersen, Henrik Baymler

AU - Hahn, Christoffer Holst

AU - Bentzen, Jens

AU - Schytte, Sten

AU - Christiansen, Peer

AU - Gerke, Oke

AU - Godballe, Christian

AU - Danish Thyroid Cancer Group-DATHYRCA (part of the DAHANCA organization)(Birte Nygaard, Peter Oturai, members)

A2 - Nygaard, Birte

A2 - Oturai, Peter Sandor

PY - 2015/1

Y1 - 2015/1

N2 - BACKGROUND: Regional as well as national series show an increasing incidence of thyroid cancer largely small size papillary thyroid carcinoma (PTC). Prognostic scoring systems have been developed, but these do not take into account the rapidly changing case mix, and adjustments may be required. The purposes of this study were to evaluate treatment outcomes and to analyze the value of older prognostic scoring systems tested on a relatively new, unselected national cohort of PTC patients.METHODS: This was a national prospective cohort study conducted in Denmark, which has a population of 5.5 million.RESULTS: A total of 1350 patients were diagnosed with PTC during 1996-2008, and the median follow-up time was 7.9 years. The 10-year recurrence-free survival rate was 90.2%, and the 10-year crude and cause-specific survival (CSS) rates were 83.7% and 93.8% respectively. By multivariate Cox regression, it was possible to confirm age, metastases (distant and nodal), extrathyroidal extension, and tumor size as predictors of mortality, whereas only nodal metastases, extrathyroidal extension, and tumor size were predictors of recurrence. In analyses of older prognostic scoring systems, a significant correlation between the risk group ranks was found for survival as well as recurrence. The c-index for CSS was highest for MACIS (0.92) and lowest for AMES (0.80). In the TNM, MACIS, and EORTC systems, most patients were classified as stage 1, and for these patients, the 10-year CSS rate was approximately 99.5%, confirming the generally excellent survival.CONCLUSION: This national study provides further evidence that a favorable prognosis is to be expected for patients diagnosed with PTC. Also, it was possible to confirm age, metastases, extrathyroidal extension, and tumor size as predictors of mortality, whereas only nodal metastases, extrathyroidal extension, and tumor size were predictors of recurrence. All the scoring systems evaluated were able to produce a highly significant risk group stratification, showing that in spite of the changes in the case mix of PTC, these systems are still applicable, and in fact contain valuable prognostic information useable for treatment planning.

AB - BACKGROUND: Regional as well as national series show an increasing incidence of thyroid cancer largely small size papillary thyroid carcinoma (PTC). Prognostic scoring systems have been developed, but these do not take into account the rapidly changing case mix, and adjustments may be required. The purposes of this study were to evaluate treatment outcomes and to analyze the value of older prognostic scoring systems tested on a relatively new, unselected national cohort of PTC patients.METHODS: This was a national prospective cohort study conducted in Denmark, which has a population of 5.5 million.RESULTS: A total of 1350 patients were diagnosed with PTC during 1996-2008, and the median follow-up time was 7.9 years. The 10-year recurrence-free survival rate was 90.2%, and the 10-year crude and cause-specific survival (CSS) rates were 83.7% and 93.8% respectively. By multivariate Cox regression, it was possible to confirm age, metastases (distant and nodal), extrathyroidal extension, and tumor size as predictors of mortality, whereas only nodal metastases, extrathyroidal extension, and tumor size were predictors of recurrence. In analyses of older prognostic scoring systems, a significant correlation between the risk group ranks was found for survival as well as recurrence. The c-index for CSS was highest for MACIS (0.92) and lowest for AMES (0.80). In the TNM, MACIS, and EORTC systems, most patients were classified as stage 1, and for these patients, the 10-year CSS rate was approximately 99.5%, confirming the generally excellent survival.CONCLUSION: This national study provides further evidence that a favorable prognosis is to be expected for patients diagnosed with PTC. Also, it was possible to confirm age, metastases, extrathyroidal extension, and tumor size as predictors of mortality, whereas only nodal metastases, extrathyroidal extension, and tumor size were predictors of recurrence. All the scoring systems evaluated were able to produce a highly significant risk group stratification, showing that in spite of the changes in the case mix of PTC, these systems are still applicable, and in fact contain valuable prognostic information useable for treatment planning.

U2 - 10.1089/thy.2014.0294

DO - 10.1089/thy.2014.0294

M3 - Journal article

C2 - 25368981

VL - 25

SP - 78

EP - 84

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - 1

ER -

ID: 45026834