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Paediatric hepatitis B and hepatitis C virus infections: an observational study of a Danish cohort

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Norden, Christoph ; Malham, Mikkel ; Nordly, Sannie ; Grosen, Dorthe ; Kvistgaard, Helene ; Kjaer, Mette S ; Brix Christensen, Vibeke. / Paediatric hepatitis B and hepatitis C virus infections : an observational study of a Danish cohort. I: Acta paediatrica. 2020 ; Bind 109, Nr. 12. s. 2694-2698.

Bibtex

@article{c30215e05e7d456296cbc7df2f49737c,
title = "Paediatric hepatitis B and hepatitis C virus infections: an observational study of a Danish cohort",
abstract = "AIM: The aim of this study was to describe the epidemiological and clinical characteristics in children with either chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection in Denmark.METHODS: In this observational study, children and adolescents with either chronic HBV or HCV infection followed at the largest paediatric departments in Denmark between 2001 and 2013 were included. Data collection included as well epidemiological data as clinical data like virus genotype, viral load, serological markers, liver biochemistry, liver elastography and histology if available.RESULTS: The study included 131 children. None of the patients had decreased liver function or end-stage liver disease during follow-up. Ten of the 18 children who underwent liver biopsy had signs of fibrosis. Thirteen (11%) children with HBV and one (7%) child with HCV received treatment. Different indications and different treatment regimens were used.CONCLUSION: This study confirms that chronic HBV and HCV infections are often mild diseases during childhood. Nevertheless, children are at higher risk of serious liver disease early in life because of the early time of infection and probably also because of the high viral loads.",
keywords = "children/adolescents, chronic hepatitis, hepatitis B virus, hepatitis C virus, liver cirrhosis",
author = "Christoph Norden and Mikkel Malham and Sannie Nordly and Dorthe Grosen and Helene Kvistgaard and Kjaer, {Mette S} and {Brix Christensen}, Vibeke",
note = "{\textcopyright} 2020 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.",
year = "2020",
month = dec,
doi = "10.1111/apa.15403",
language = "English",
volume = "109",
pages = "2694--2698",
journal = "Acta paediatrica",
issn = "1651-2227",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "12",

}

RIS

TY - JOUR

T1 - Paediatric hepatitis B and hepatitis C virus infections

T2 - an observational study of a Danish cohort

AU - Norden, Christoph

AU - Malham, Mikkel

AU - Nordly, Sannie

AU - Grosen, Dorthe

AU - Kvistgaard, Helene

AU - Kjaer, Mette S

AU - Brix Christensen, Vibeke

N1 - © 2020 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

PY - 2020/12

Y1 - 2020/12

N2 - AIM: The aim of this study was to describe the epidemiological and clinical characteristics in children with either chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection in Denmark.METHODS: In this observational study, children and adolescents with either chronic HBV or HCV infection followed at the largest paediatric departments in Denmark between 2001 and 2013 were included. Data collection included as well epidemiological data as clinical data like virus genotype, viral load, serological markers, liver biochemistry, liver elastography and histology if available.RESULTS: The study included 131 children. None of the patients had decreased liver function or end-stage liver disease during follow-up. Ten of the 18 children who underwent liver biopsy had signs of fibrosis. Thirteen (11%) children with HBV and one (7%) child with HCV received treatment. Different indications and different treatment regimens were used.CONCLUSION: This study confirms that chronic HBV and HCV infections are often mild diseases during childhood. Nevertheless, children are at higher risk of serious liver disease early in life because of the early time of infection and probably also because of the high viral loads.

AB - AIM: The aim of this study was to describe the epidemiological and clinical characteristics in children with either chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection in Denmark.METHODS: In this observational study, children and adolescents with either chronic HBV or HCV infection followed at the largest paediatric departments in Denmark between 2001 and 2013 were included. Data collection included as well epidemiological data as clinical data like virus genotype, viral load, serological markers, liver biochemistry, liver elastography and histology if available.RESULTS: The study included 131 children. None of the patients had decreased liver function or end-stage liver disease during follow-up. Ten of the 18 children who underwent liver biopsy had signs of fibrosis. Thirteen (11%) children with HBV and one (7%) child with HCV received treatment. Different indications and different treatment regimens were used.CONCLUSION: This study confirms that chronic HBV and HCV infections are often mild diseases during childhood. Nevertheless, children are at higher risk of serious liver disease early in life because of the early time of infection and probably also because of the high viral loads.

KW - children/adolescents

KW - chronic hepatitis

KW - hepatitis B virus

KW - hepatitis C virus

KW - liver cirrhosis

UR - http://www.scopus.com/inward/record.url?scp=85087303588&partnerID=8YFLogxK

U2 - 10.1111/apa.15403

DO - 10.1111/apa.15403

M3 - Journal article

C2 - 32506543

VL - 109

SP - 2694

EP - 2698

JO - Acta paediatrica

JF - Acta paediatrica

SN - 1651-2227

IS - 12

ER -

ID: 60014143