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Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients

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Harvard

Dijkland, SA, Helmrich, IRAR, Nieboer, D, van der Jagt, M, Dippel, DWJ, Menon, DK, Stocchetti, N, Maas, AIR, Lingsma, HF, Steyerberg, EW, CENTER-TBI Participants and Investigators, Fabricius, ME & Kondziella, D 2021, 'Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients', Journal of Neurotrauma, bind 38, nr. 10, s. 1377-1388. https://doi.org/10.1089/neu.2020.7300

APA

Dijkland, S. A., Helmrich, I. R. A. R., Nieboer, D., van der Jagt, M., Dippel, D. W. J., Menon, D. K., Stocchetti, N., Maas, A. I. R., Lingsma, H. F., Steyerberg, E. W., CENTER-TBI Participants and Investigators, Fabricius, M. E., & Kondziella, D. (2021). Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients. Journal of Neurotrauma, 38(10), 1377-1388. https://doi.org/10.1089/neu.2020.7300

CBE

Dijkland SA, Helmrich IRAR, Nieboer D, van der Jagt M, Dippel DWJ, Menon DK, Stocchetti N, Maas AIR, Lingsma HF, Steyerberg EW, CENTER-TBI Participants and Investigators, Fabricius ME, Kondziella D. 2021. Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients. Journal of Neurotrauma. 38(10):1377-1388. https://doi.org/10.1089/neu.2020.7300

MLA

Vancouver

Author

Dijkland, Simone A ; Helmrich, Isabel R A Retel ; Nieboer, Daan ; van der Jagt, Mathieu ; Dippel, Diederik W J ; Menon, David K ; Stocchetti, Nino ; Maas, Andrew I R ; Lingsma, Hester F ; Steyerberg, Ewout W ; CENTER-TBI Participants and Investigators ; Fabricius, Martin Ejler ; Kondziella, Daniel. / Outcome Prediction after Moderate and Severe Traumatic Brain Injury : External Validation of Two Established Prognostic Models in 1742 European Patients. I: Journal of Neurotrauma. 2021 ; Bind 38, Nr. 10. s. 1377-1388.

Bibtex

@article{5a91adbf5d604d01b9ae263fc6ae4edb,
title = "Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients",
abstract = "The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models predict functional outcome after moderate and severe traumatic brain injury (TBI). We aimed to assess their performance in a contemporary cohort of patients across Europe. The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) core study is a prospective, observational cohort study in patients presenting with TBI and an indication for brain computed tomography. The CENTER-TBI core cohort consists of 4509 TBI patients available for analyses from 59 centers in 18 countries across Europe and Israel. The IMPACT validation cohort included 1173 patients with GCS ≤12, age ≥14, and 6-month Glasgow Outcome Scale-Extended (GOSE) available. The CRASH validation cohort contained 1742 patients with GCS ≤14, age ≥16, and 14-day mortality or 6-month GOSE available. Performance of the three IMPACT and two CRASH model variants was assessed with discrimination (area under the receiver operating characteristic curve; AUC) and calibration (comparison of observed vs. predicted outcome rates). For IMPACT, model discrimination was good, with AUCs ranging between 0.77 and 0.85 in 1173 patients and between 0.80 and 0.88 in the broader CRASH selection (n = 1742). For CRASH, AUCs ranged between 0.82 and 0.88 in 1742 patients and between 0.66 and 0.80 in the stricter IMPACT selection (n = 1173). Calibration of the IMPACT and CRASH models was generally moderate, with calibration-in-the-large and calibration slopes ranging between -2.02 and 0.61 and between 0.48 and 1.39, respectively. The IMPACT and CRASH models adequately identify patients at high risk for mortality or unfavorable outcome, which supports their use in research settings and for benchmarking in the context of quality-of-care assessment.",
keywords = "clinical prediction model, external validation, outcome, prognosis, traumatic brain injury",
author = "Dijkland, {Simone A} and Helmrich, {Isabel R A Retel} and Daan Nieboer and {van der Jagt}, Mathieu and Dippel, {Diederik W J} and Menon, {David K} and Nino Stocchetti and Maas, {Andrew I R} and Lingsma, {Hester F} and Steyerberg, {Ewout W} and {CENTER-TBI Participants and Investigators} and Fabricius, {Martin Ejler} and Daniel Kondziella",
year = "2021",
month = may,
day = "15",
doi = "10.1089/neu.2020.7300",
language = "English",
volume = "38",
pages = "1377--1388",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Outcome Prediction after Moderate and Severe Traumatic Brain Injury

T2 - External Validation of Two Established Prognostic Models in 1742 European Patients

AU - Dijkland, Simone A

AU - Helmrich, Isabel R A Retel

AU - Nieboer, Daan

AU - van der Jagt, Mathieu

AU - Dippel, Diederik W J

AU - Menon, David K

AU - Stocchetti, Nino

AU - Maas, Andrew I R

AU - Lingsma, Hester F

AU - Steyerberg, Ewout W

AU - CENTER-TBI Participants and Investigators

A2 - Fabricius, Martin Ejler

A2 - Kondziella, Daniel

PY - 2021/5/15

Y1 - 2021/5/15

N2 - The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models predict functional outcome after moderate and severe traumatic brain injury (TBI). We aimed to assess their performance in a contemporary cohort of patients across Europe. The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) core study is a prospective, observational cohort study in patients presenting with TBI and an indication for brain computed tomography. The CENTER-TBI core cohort consists of 4509 TBI patients available for analyses from 59 centers in 18 countries across Europe and Israel. The IMPACT validation cohort included 1173 patients with GCS ≤12, age ≥14, and 6-month Glasgow Outcome Scale-Extended (GOSE) available. The CRASH validation cohort contained 1742 patients with GCS ≤14, age ≥16, and 14-day mortality or 6-month GOSE available. Performance of the three IMPACT and two CRASH model variants was assessed with discrimination (area under the receiver operating characteristic curve; AUC) and calibration (comparison of observed vs. predicted outcome rates). For IMPACT, model discrimination was good, with AUCs ranging between 0.77 and 0.85 in 1173 patients and between 0.80 and 0.88 in the broader CRASH selection (n = 1742). For CRASH, AUCs ranged between 0.82 and 0.88 in 1742 patients and between 0.66 and 0.80 in the stricter IMPACT selection (n = 1173). Calibration of the IMPACT and CRASH models was generally moderate, with calibration-in-the-large and calibration slopes ranging between -2.02 and 0.61 and between 0.48 and 1.39, respectively. The IMPACT and CRASH models adequately identify patients at high risk for mortality or unfavorable outcome, which supports their use in research settings and for benchmarking in the context of quality-of-care assessment.

AB - The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models predict functional outcome after moderate and severe traumatic brain injury (TBI). We aimed to assess their performance in a contemporary cohort of patients across Europe. The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) core study is a prospective, observational cohort study in patients presenting with TBI and an indication for brain computed tomography. The CENTER-TBI core cohort consists of 4509 TBI patients available for analyses from 59 centers in 18 countries across Europe and Israel. The IMPACT validation cohort included 1173 patients with GCS ≤12, age ≥14, and 6-month Glasgow Outcome Scale-Extended (GOSE) available. The CRASH validation cohort contained 1742 patients with GCS ≤14, age ≥16, and 14-day mortality or 6-month GOSE available. Performance of the three IMPACT and two CRASH model variants was assessed with discrimination (area under the receiver operating characteristic curve; AUC) and calibration (comparison of observed vs. predicted outcome rates). For IMPACT, model discrimination was good, with AUCs ranging between 0.77 and 0.85 in 1173 patients and between 0.80 and 0.88 in the broader CRASH selection (n = 1742). For CRASH, AUCs ranged between 0.82 and 0.88 in 1742 patients and between 0.66 and 0.80 in the stricter IMPACT selection (n = 1173). Calibration of the IMPACT and CRASH models was generally moderate, with calibration-in-the-large and calibration slopes ranging between -2.02 and 0.61 and between 0.48 and 1.39, respectively. The IMPACT and CRASH models adequately identify patients at high risk for mortality or unfavorable outcome, which supports their use in research settings and for benchmarking in the context of quality-of-care assessment.

KW - clinical prediction model

KW - external validation

KW - outcome

KW - prognosis

KW - traumatic brain injury

U2 - 10.1089/neu.2020.7300

DO - 10.1089/neu.2020.7300

M3 - Journal article

C2 - 33161840

VL - 38

SP - 1377

EP - 1388

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 10

ER -

ID: 61991421