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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Outcome after translabyrinthine surgery for vestibular schwannomas: report on 1244 patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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The objective of this article is to study the outcome after translabyrinthine surgery for vestibular schwannomas, with special focus on the facial nerve function. The study design is a case series from a national centralized database and it is set in two University Hospitals in Denmark. Participants were 1244 patients who underwent translabyrinthine surgery during a period of 33 years from 1976 to 2009. Main outcome measures were tumor removal, intraoperative facial nerve preservation, complications, and postoperative facial nerve function. In 84% patients, the tumor was totally resected and in ~85% the nerve was intact during surgery. During 33 years, 12 patients died from complications to surgery and ~14% had cerebrospinal fluid leakage. Before surgery, 74 patients had facial paresis and 46% of these improved after surgery. In patients with normal facial function, overall ~70% had a good outcome (House-Brackmann grade 1 or 2). The chance of a good outcome was related to tumor size with a higher the chance the smaller the tumor, but not to the degree of tumor removal. In ~78% of the patients with facial paresis at discharge the paresis improved over time, in ~42% from a poor to a good function. The translabyrinthine approach is generally efficient in tumor control and with satisfactory facial nerve outcome. With larger tumors the risk of a poor outcome is evident and more data on patients managed with alternative strategies are warranted.
OriginalsprogEngelsk
TidsskriftJournal of neurological surgery. Part B, Skull base
Vol/bind73
Udgave nummer3
Sider (fra-til)168-74
Antal sider7
ISSN2193-6331
DOI
StatusUdgivet - jun. 2012

ID: 40963310