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Orbital Lymphoma - An International Multicenter Retrospective Study

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Olsen, TG, Holm, F, Mikkelsen, LH, Rasmussen, PK, Coupland, SE, Esmaeli, B, Finger, PT, Graue, GF, Grossniklaus, HE, Honavar, SG, Khong, JJ, McKelvie, PA, Mulay, K, Sjö, LD, Vemuganti, GK, Thuro, BA & Heegaard, S 2019, 'Orbital Lymphoma - An International Multicenter Retrospective Study' American Journal of Ophthalmology, bind 199, s. 44-57. https://doi.org/10.1016/j.ajo.2018.11.002

APA

CBE

Olsen TG, Holm F, Mikkelsen LH, Rasmussen PK, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Khong JJ, McKelvie PA, Mulay K, Sjö LD, Vemuganti GK, Thuro BA, Heegaard S. 2019. Orbital Lymphoma - An International Multicenter Retrospective Study. American Journal of Ophthalmology. 199:44-57. https://doi.org/10.1016/j.ajo.2018.11.002

MLA

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Author

Olsen, Tine Gadegaard ; Holm, Frederik ; Mikkelsen, Lauge Hjorth ; Rasmussen, Peter Kristian ; Coupland, Sarah E ; Esmaeli, Bita ; Finger, Paul T ; Graue, Gerardo F ; Grossniklaus, Hans E ; Honavar, Santosh G ; Khong, Jwu Jin ; McKelvie, Penelope A ; Mulay, Kaustubh ; Sjö, Lene Dissing ; Vemuganti, Geeta K ; Thuro, Bradley A ; Heegaard, Steffen. / Orbital Lymphoma - An International Multicenter Retrospective Study. I: American Journal of Ophthalmology. 2019 ; Bind 199. s. 44-57.

Bibtex

@article{1f61ac69021a46b994f597a9c73e5657,
title = "Orbital Lymphoma - An International Multicenter Retrospective Study",
abstract = "PURPOSE: To investigate and characterize the clinical features of subtype-specific orbital lymphoma.DESIGN: Retrospective, interventional case series.METHODS: The study included 7 international eye cancer centers. Patient data were collected from January 1, 1980 through December 31, 2017. A total of 797 patients with a histologically verified orbital lymphoma were included. The primary end points were overall survival, disease-specific survival and progression-free survival.RESULTS: The median age was 64 years, and 51{\%} of patients were male. The majority of lymphomas were of B-cell origin (98{\%}, n = 779). Extranodal marginal zone B-cell lymphoma (EMZL) was the most frequent subtype (57{\%}, n = 452), followed by diffuse large B-cell lymphoma (DLBCL) (15{\%}, n = 118), follicular lymphoma (FL) (11{\%}, n = 91), and mantle cell lymphoma (MCL) (8{\%}, n = 66). Localized Ann Arbor stage IE EMZL and FL were frequently treated with external beam radiation therapy. DLBCL, MCL and disseminated EMZL and FL were primarily treated with chemotherapy. EMZL and FL patients had a markedly better prognosis (10-year disease-specific survival of 92{\%} and 71{\%}, respectively) than DLBCL and MCL patients (10-year disease-specific survival of 41{\%} and 32{\%}, respectively).CONCLUSIONS: and Relevance: Four lymphoma subtypes were primarily found in patients with orbital lymphoma: EMZL, DLBCL, FL, and MCL. The histological subtype was found to be the main predictor for outcome, with EMZL and FL patients having a markedly better prognosis than DLBCL and MCL.",
author = "Olsen, {Tine Gadegaard} and Frederik Holm and Mikkelsen, {Lauge Hjorth} and Rasmussen, {Peter Kristian} and Coupland, {Sarah E} and Bita Esmaeli and Finger, {Paul T} and Graue, {Gerardo F} and Grossniklaus, {Hans E} and Honavar, {Santosh G} and Khong, {Jwu Jin} and McKelvie, {Penelope A} and Kaustubh Mulay and Sj{\"o}, {Lene Dissing} and Vemuganti, {Geeta K} and Thuro, {Bradley A} and Steffen Heegaard",
note = "Copyright {\circledC} 2018. Published by Elsevier Inc.",
year = "2019",
doi = "10.1016/j.ajo.2018.11.002",
language = "English",
volume = "199",
pages = "44--57",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier Inc",

}

RIS

TY - JOUR

T1 - Orbital Lymphoma - An International Multicenter Retrospective Study

AU - Olsen, Tine Gadegaard

AU - Holm, Frederik

AU - Mikkelsen, Lauge Hjorth

AU - Rasmussen, Peter Kristian

AU - Coupland, Sarah E

AU - Esmaeli, Bita

AU - Finger, Paul T

AU - Graue, Gerardo F

AU - Grossniklaus, Hans E

AU - Honavar, Santosh G

AU - Khong, Jwu Jin

AU - McKelvie, Penelope A

AU - Mulay, Kaustubh

AU - Sjö, Lene Dissing

AU - Vemuganti, Geeta K

AU - Thuro, Bradley A

AU - Heegaard, Steffen

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2019

Y1 - 2019

N2 - PURPOSE: To investigate and characterize the clinical features of subtype-specific orbital lymphoma.DESIGN: Retrospective, interventional case series.METHODS: The study included 7 international eye cancer centers. Patient data were collected from January 1, 1980 through December 31, 2017. A total of 797 patients with a histologically verified orbital lymphoma were included. The primary end points were overall survival, disease-specific survival and progression-free survival.RESULTS: The median age was 64 years, and 51% of patients were male. The majority of lymphomas were of B-cell origin (98%, n = 779). Extranodal marginal zone B-cell lymphoma (EMZL) was the most frequent subtype (57%, n = 452), followed by diffuse large B-cell lymphoma (DLBCL) (15%, n = 118), follicular lymphoma (FL) (11%, n = 91), and mantle cell lymphoma (MCL) (8%, n = 66). Localized Ann Arbor stage IE EMZL and FL were frequently treated with external beam radiation therapy. DLBCL, MCL and disseminated EMZL and FL were primarily treated with chemotherapy. EMZL and FL patients had a markedly better prognosis (10-year disease-specific survival of 92% and 71%, respectively) than DLBCL and MCL patients (10-year disease-specific survival of 41% and 32%, respectively).CONCLUSIONS: and Relevance: Four lymphoma subtypes were primarily found in patients with orbital lymphoma: EMZL, DLBCL, FL, and MCL. The histological subtype was found to be the main predictor for outcome, with EMZL and FL patients having a markedly better prognosis than DLBCL and MCL.

AB - PURPOSE: To investigate and characterize the clinical features of subtype-specific orbital lymphoma.DESIGN: Retrospective, interventional case series.METHODS: The study included 7 international eye cancer centers. Patient data were collected from January 1, 1980 through December 31, 2017. A total of 797 patients with a histologically verified orbital lymphoma were included. The primary end points were overall survival, disease-specific survival and progression-free survival.RESULTS: The median age was 64 years, and 51% of patients were male. The majority of lymphomas were of B-cell origin (98%, n = 779). Extranodal marginal zone B-cell lymphoma (EMZL) was the most frequent subtype (57%, n = 452), followed by diffuse large B-cell lymphoma (DLBCL) (15%, n = 118), follicular lymphoma (FL) (11%, n = 91), and mantle cell lymphoma (MCL) (8%, n = 66). Localized Ann Arbor stage IE EMZL and FL were frequently treated with external beam radiation therapy. DLBCL, MCL and disseminated EMZL and FL were primarily treated with chemotherapy. EMZL and FL patients had a markedly better prognosis (10-year disease-specific survival of 92% and 71%, respectively) than DLBCL and MCL patients (10-year disease-specific survival of 41% and 32%, respectively).CONCLUSIONS: and Relevance: Four lymphoma subtypes were primarily found in patients with orbital lymphoma: EMZL, DLBCL, FL, and MCL. The histological subtype was found to be the main predictor for outcome, with EMZL and FL patients having a markedly better prognosis than DLBCL and MCL.

U2 - 10.1016/j.ajo.2018.11.002

DO - 10.1016/j.ajo.2018.11.002

M3 - Journal article

VL - 199

SP - 44

EP - 57

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

ER -

ID: 56362005