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Orbital lymphoma

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@article{edb6012e9e3b404380dc18034dd46f56,
title = "Orbital lymphoma",
abstract = "Orbital lymphomas constitute 50-60{\%} of ocular adnexal lymphomas. A total of 2211 cases of orbital lymphoma with a known subtype have been reported in the last 24 years (1994-2017). The vast majority of orbital lymphomas are of B-cell origin (97{\%}), of which extranodal marginal zone B-cell lymphoma (EMZL) (59{\%}) is the most common subtype, followed by diffuse large B-cell lymphoma (23{\%}), follicular lymphoma (9{\%}), and mantle cell lymphoma (5{\%}). Orbital lymphoma is primarily a disease of the elderly. Gender distribution varies according to lymphoma subtype. However, extranodal marginal zone B-cell lymphoma (53{\%}) and follicular lymphoma (75{\%}) show a female predominance, whereas diffuse large B-cell lymphoma shows an even gender distribution. Mantle cell lymphoma has a striking male predominance of 80{\%}. The histopathological subtype and the clinical stage of the disease are the best indicators of prognosis and patient outcome. Low-grade lymphomas such as extranodal marginal zone B-cell lymphoma and FL have a good prognosis, whereas high-grade lymphomas (diffuse large B-cell lymphoma and mantle cell lymphoma) are associated with a poor prognosis. When managing solitary low-grade lymphomas, radiotherapy is the treatment of choice. Chemotherapy, with or without radiotherapy, should be chosen for disseminated and high-grade lymphomas.",
keywords = "Combined Modality Therapy, Global Health, Humans, Incidence, Lymphoma/diagnosis, Orbit/diagnostic imaging, Orbital Neoplasms/diagnosis, Survival Rate/trends",
author = "Olsen, {Tine Gadegaard} and Steffen Heegaard",
note = "Copyright {\circledC} 2018 Elsevier Inc. All rights reserved.",
year = "2019",
month = "1",
doi = "10.1016/j.survophthal.2018.08.002",
language = "English",
volume = "64",
pages = "45--66",
journal = "Survey of Ophthalmology",
issn = "0039-6257",
publisher = "Elsevier Inc",
number = "1",

}

RIS

TY - JOUR

T1 - Orbital lymphoma

AU - Olsen, Tine Gadegaard

AU - Heegaard, Steffen

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2019/1

Y1 - 2019/1

N2 - Orbital lymphomas constitute 50-60% of ocular adnexal lymphomas. A total of 2211 cases of orbital lymphoma with a known subtype have been reported in the last 24 years (1994-2017). The vast majority of orbital lymphomas are of B-cell origin (97%), of which extranodal marginal zone B-cell lymphoma (EMZL) (59%) is the most common subtype, followed by diffuse large B-cell lymphoma (23%), follicular lymphoma (9%), and mantle cell lymphoma (5%). Orbital lymphoma is primarily a disease of the elderly. Gender distribution varies according to lymphoma subtype. However, extranodal marginal zone B-cell lymphoma (53%) and follicular lymphoma (75%) show a female predominance, whereas diffuse large B-cell lymphoma shows an even gender distribution. Mantle cell lymphoma has a striking male predominance of 80%. The histopathological subtype and the clinical stage of the disease are the best indicators of prognosis and patient outcome. Low-grade lymphomas such as extranodal marginal zone B-cell lymphoma and FL have a good prognosis, whereas high-grade lymphomas (diffuse large B-cell lymphoma and mantle cell lymphoma) are associated with a poor prognosis. When managing solitary low-grade lymphomas, radiotherapy is the treatment of choice. Chemotherapy, with or without radiotherapy, should be chosen for disseminated and high-grade lymphomas.

AB - Orbital lymphomas constitute 50-60% of ocular adnexal lymphomas. A total of 2211 cases of orbital lymphoma with a known subtype have been reported in the last 24 years (1994-2017). The vast majority of orbital lymphomas are of B-cell origin (97%), of which extranodal marginal zone B-cell lymphoma (EMZL) (59%) is the most common subtype, followed by diffuse large B-cell lymphoma (23%), follicular lymphoma (9%), and mantle cell lymphoma (5%). Orbital lymphoma is primarily a disease of the elderly. Gender distribution varies according to lymphoma subtype. However, extranodal marginal zone B-cell lymphoma (53%) and follicular lymphoma (75%) show a female predominance, whereas diffuse large B-cell lymphoma shows an even gender distribution. Mantle cell lymphoma has a striking male predominance of 80%. The histopathological subtype and the clinical stage of the disease are the best indicators of prognosis and patient outcome. Low-grade lymphomas such as extranodal marginal zone B-cell lymphoma and FL have a good prognosis, whereas high-grade lymphomas (diffuse large B-cell lymphoma and mantle cell lymphoma) are associated with a poor prognosis. When managing solitary low-grade lymphomas, radiotherapy is the treatment of choice. Chemotherapy, with or without radiotherapy, should be chosen for disseminated and high-grade lymphomas.

KW - Combined Modality Therapy

KW - Global Health

KW - Humans

KW - Incidence

KW - Lymphoma/diagnosis

KW - Orbit/diagnostic imaging

KW - Orbital Neoplasms/diagnosis

KW - Survival Rate/trends

U2 - 10.1016/j.survophthal.2018.08.002

DO - 10.1016/j.survophthal.2018.08.002

M3 - Review

VL - 64

SP - 45

EP - 66

JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

SN - 0039-6257

IS - 1

ER -

ID: 56468532