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Rigshospitalet - en del af Københavns Universitetshospital
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Observational cohort study of rilpivirine (RPV) utilization in Europe

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Immune reconstitution syndrome presenting as probable AIDS-related lymphoma: a case report

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Alessandro Cozzi-Lepri
  • Lars Peters
  • Annegret Pelchen-Matthews
  • Bastian Neesgaard
  • Stephane De Wit
  • Isik Somuncu Johansen
  • Simon Edwards
  • Christoph Stephan
  • Georgios Adamis
  • Therese Staub
  • Alexandra Zagalo
  • Pere Domingo
  • Daniel Elbirt
  • Katharina Kusejko
  • Johanna Brännström
  • Dzmitry Paduta
  • Tatyana Trofimova
  • Janos Szlavik
  • Kai Zilmer
  • Marcello Losso
  • Veerle Van Eygen
  • Helen Pai
  • Jens Lundgren
  • Amanda Mocroft
  • EuroSIDA study group
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INTRODUCTION: Data on safety and effectiveness of RPV from the real-world setting as well as comparisons with other NNRTIs such as efavirenz (EFV) remain scarce. METHODS: Participants of EuroSIDA were included if they had started a RPV- or an EFV-containing regimen over November 2011-December 2017. Statistical testing was conducted using non-parametric Mann-Whitney U test and Chi-square test. A logistic regression model was used to compare participants' characteristics by treatment group. Kaplan-Meier analysis was used to estimate the cumulative risk of virological failure (VF, two consecutive values > 50 copies/mL). RESULTS: 1,355 PLWH who started a RPV-based regimen (11% ART-naïve), as well as 333 initiating an EFV-containing regimen were included. Participants who started RPV differed from those starting EFV for demographics (age, geographical region) and immune-virological profiles (CD4 count, HIV RNA). The cumulative risk of VF for the RPV-based group was 4.5% (95% CI 3.3-5.7%) by 2 years from starting treatment (71 total VF events). Five out of 15 (33%) with resistance data available in the RPV group showed resistance-associated mutations vs. 3/13 (23%) among those in the EFV group. Discontinuations due to intolerance/toxicity were reported for 73 (15%) of RPV- vs. 45 (30%) of EFV-treated participants (p = 0.0001). The main difference was for toxicity of central nervous system (CNS, 3% vs. 22%, p < 0.001). CONCLUSION: Our estimates of VF > 50 copies/mL and resistance in participants treated with RPV were similar to those reported by other studies. RPV safety profile was favourable with less frequent discontinuation due to toxicity than EFV (especially for CNS).

OriginalsprogEngelsk
Artikelnummer38
TidsskriftAIDS Research and Therapy
Vol/bind19
Udgave nummer1
Sider (fra-til)38
Antal sider1
ISSN1742-6405
DOI
StatusUdgivet - 6 aug. 2022

Bibliografisk note

© 2022. The Author(s).

ID: 80348862