Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Biological optimization for mediastinal lymphoma radiotherapy - a preliminary study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. eHealth-mind the gap

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Tumour control probability after Ruthenium-106 brachytherapy for choroidal melanomas

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Circulating tumour DNA alterations as biomarkers for head and neck cancer: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The current epidemic of HPV-associated oropharyngeal cancer: An 18-year Danish population-based study with 2,169 patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. High nodal FDG uptake increases risk of distant metastasis in patients with oropharyngeal squamous cell carcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Radiation dose-painting with protons vs. photons for head-and-neck cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • C R Hansen
  • J Friborg
  • K Jensen
  • E Samsøe
  • L Johnsen
  • R Zukauskaite
  • C Grau
  • C Maare
  • J Johansen
  • H Primdahl
  • Å Bratland
  • C A Kristensen
  • M Andersen
  • J G Eriksen
  • J Overgaard
Vis graf over relationer

Introduction: Prediction models using logistic regression may perform poorly in external patient cohorts. However, there is a need to standardize and validate models for clinical use. The purpose of this project was to describe a method for validation of external NTCP models used for patient selection in the randomized trial of protons versus photons in head and neck cancer radiotherapy, DAHANCA 35. Material and methods: Organs at risk of 588 patients treated primarily with IMRT in the randomized controlled DAHANCA19 trial were retrospectively contoured according to recent international recommendations. Dose metrics were extracted using MatLab and all clinical parameters were retrieved from the DAHANCA database. The model proposed by Christianen et al. to predict physician-rated dysphagia was validated through the closed testing, where change of the model intercept, slope and individual beta's were tested for significant prediction improvements. Results: Six months prevalence of dysphagia in the validation cohort was 33%. The closed testing procedure for physician-rated dysphagia showed that the Christianen et al. model needed an intercept refitting for the best match for the Danish patients. The intercept update increased the risk of dysphagia for the validation cohort by 7.9 ± 2.5% point. For the raw model performance, the Brier score (mean squared residual) was 0.467, which improved significantly with a new intercept to 0.415. Conclusions: The previously published Dutch dysphagia model needed an intercept update to match the Danish patient cohort. The implementation of a closed testing procedure on the current validation cohort allows quick and efficient validation of external NTCP models for patient selection in the future.

OriginalsprogEngelsk
TidsskriftActa oncologica
Vol/bind58
Udgave nummer10
Sider (fra-til)1410-1415
Antal sider6
ISSN0284-186X
DOI
StatusUdgivet - 3 okt. 2019

ID: 58596458