Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Non-epithelial ovarian cancer in Denmark - Incidence and survival over nearly 40 years

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Incidence of vulvar high-grade precancerous lesions and cancer in Denmark before and after introduction of HPV vaccination

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk of endometrial cancer among women with benign ovarian tumors - A Danish nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Human papillomavirus genotype-specific risks for cervical intraepithelial lesions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Borderline ovarian tumors in Denmark 1997-2018: Time trends in incidence by histology, age and educational level

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Low-dose aspirin use and risk of head and neck cancer-A Danish nationwide case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Endometrial cancer risk after fertility treatment: a population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • A K K Bennetsen
  • L Baandrup
  • G L Aalborg
  • S K Kjaer
Vis graf over relationer

OBJECTIVE: To examine trends in incidence and survival of non-epithelial ovarian cancer in Denmark over nearly 40 years, using nationwide, population-based cancer registry data.

METHODS: From 1978 to 2016, we identified the non-epithelial ovarian cancer cases among all ovarian malignancies in the Danish Cancer Registry. Age-specific incidence rates, age-standardized incidence rates, and average annual percentage change (AAPC) were estimated with 95% confidence intervals (CIs). Overall and 5-year relative survival analyses were conducted and supplemented with Cox regression to explore the effect of different characteristics on overall mortality.

RESULTS: A total of 720 non-epithelial ovarian cancers were identified, corresponding to 3.4% of all ovarian malignancies. The majority of non-epithelial ovarian cancers were germ cell tumors (49.9%) and sex cord-stromal tumors (38.6%). The age-standardized incidence rate of germ cell tumors was stable over the study period, ranging between 0.33 and 0.39 per 100,000 woman-years. In contrast, the age-standardized incidence rate of sex cord-stromal tumors declined from 0.30 (1978-1987) to 0.09 (2008-2016) per 100,000 woman-years (AAPC = -5.15%; 95% CI: -7.29, -2.96). The 5-year relative survival of germ cell tumors and sex cord-stromal tumors was 94% and 79%, respectively, in the most recent period (2008-2011). Cox regression showed that overall mortality was associated with calendar year, age, and stage.

CONCLUSIONS: The incidence of germ cell tumors was stable over calendar time, whereas the incidence of sex cord-stromal tumors decreased significantly. Non-epithelial ovarian cancer overall mortality has decreased during the study period and this could not be explained by taking stage and age at diagnosis into account.

OriginalsprogEngelsk
TidsskriftGynecologic Oncology
Vol/bind157
Udgave nummer3
Sider (fra-til)693-699
Antal sider7
ISSN0090-8258
DOI
StatusUdgivet - jun. 2020

Bibliografisk note

Copyright © 2020 Elsevier Inc. All rights reserved.

ID: 61557993