Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Neutrophil-to-lymphocyte ratio and CRP as biomarkers in multiple sclerosis: A systematic review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Six generations of CHMP2B-mediated Frontotemporal Dementia: Clinical features, predictive testing, progression, and survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Stroke admissions and revascularization treatments in Denmark during COVID-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Does continuous electroencephalography influence therapeutic decisions in neurocritical care?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Quality of life in chronic inflammatory demyelinating polyneuropathy patients treated with subcutaneous immunoglobulin

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Ofatumumab Modulates Inflammatory T Cell Responses and Migratory Potential in Patients With Multiple Sclerosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pregnancy in women with MS: Impact on long-term disability accrual in a nationwide Danish Cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Ocrelizumab treatment in multiple sclerosis: A Danish population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system, which causes demyelination and neuroaxonal damage. Low-grade systemic inflammation has been suggested to contribute to the pathogenesis due to amplification of pathogenic immune activation. However, there is a lack of reliable biomarkers of systemic inflammation predicting disease activity and progression in MS. The neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) have been identified as biomarkers of severity and disease activity in various disorders. In September 2020, we conducted a systematic literature search on multiple databases on studies reporting NLR values or CRP levels in MS. The aim of this systematic review was to highlight the current knowledge about the potential of NLR and CRP as biomarkers in MS. A total of nineteen articles qualified for inclusion. Data on CRP were included in fourteen studies and NLR in nine studies. The results regarding CRP were inconsistent, and present literature does not support the use of CRP as a diagnostic or prognostic biomarker in MS. In contrast, NLR values were increased in MS patients compared with healthy controls in all case-control studies. Furthermore, NLR was associated with disease activity in untreated patients. Our systematic review therefore indicates that NLR might serve as a potential biomarker of disease activity. Given that the results of NLR are mainly drawn from retrospective case-control or cross-sectional studies, future prospective studies with long-term follow-up are required to accurately determine optimal timing and cutoff values that may be used in the clinical setting.

OriginalsprogEngelsk
TidsskriftActa Neurologica Scandinavica
Vol/bind143
Udgave nummer6
Sider (fra-til)577-586
Antal sider10
ISSN0001-6314
DOI
StatusUdgivet - jun. 2021

Bibliografisk note

© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

ID: 72970893