Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Non-Invasive Fetal K Status Prediction: 7 Years of Experience

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cellular and antibody response in GMZ2-vaccinated Gabonese volunteers in a controlled human malaria infection trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Antibody-mediated opsonic phagocytosis (OP) of Plasmodium falciparum blood-stage merozoites has been associated with protection against malaria. However, the precise contribution of different peripheral blood phagocytes in the OP mechanism remains unknown. Here, we developed an in vitro OP assay using peripheral blood leukocytes that allowed us to quantify the contribution of each phagocytic cell type in the OP of merozoites. We found that CD14 + +CD16- monocytes were the dominant phagocytic cells at very low antibody levels and Fc gamma receptor (FcγR) IIA plays a key role. At higher antibody levels however, neutrophils were the main phagocytes in the OP of merozoites with FcγRIIIB acting synergistically with FcγRIIA in the process. We found that OP activity by neutrophils was strongly associated with protection against febrile malaria in longitudinal cohort studies performed in Ghana and India. Our results demonstrate that peripheral blood neutrophils are the main phagocytes of P. falciparum blood-stage merozoites.

OriginalsprogEngelsk
Artikelnummer984
TidsskriftCommunications biology
Vol/bind4
Udgave nummer1
Sider (fra-til)984
ISSN2399-3642
DOI
StatusUdgivet - 19 aug. 2021

Bibliografisk note

© 2021. The Author(s).

ID: 75135844