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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Neutrophil extracellular traps - the dark side of neutrophils

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Ole E Sørensen
  • Niels Borregaard
Vis graf over relationer

Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation in vivo. NETs may spur formation of autoantibodies and may also serve as scaffolds for thrombosis, thereby providing a link among infection, autoimmunity, and thrombosis. In this review, we present the mechanisms by which NETs are formed and discuss the physiological and pathophysiological consequences of NET formation. We conclude that NETs may be of more importance in autoimmunity and thrombosis than in innate immune defense.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical investigation
Vol/bind126
Udgave nummer5
Sider (fra-til)1612-20
Antal sider9
ISSN0021-9738
DOI
StatusUdgivet - 2 maj 2016

ID: 49632174