Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

"Myocardial CT perfusion compared with transthoracic Doppler echocardiography in evaluation of the coronary microvascular function: An iPOWER substudy"

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Cardiorespiratory responses to high intensity skeletal muscle metaboreflex activation in chronic obstructive pulmonary disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Prognostic impact of ventilation-perfusion defects and pulmonary diffusing capacity after single lung transplantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The age-related reduction in cerebral blood flow affects vertebral artery more than internal carotid artery blood flow

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. I-MIBG imaging for detection of anthracycline-induced cardiomyopathy

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Vital exhaustion in women with chest pain and no obstructive coronary artery disease: the iPOWER study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Impaired coronary flow velocity reserve is associated with cardiovascular risk factors but not with angina symptoms

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Daria Frestad Bechsgaard
  • Jens Dahlgaard Hove
  • Marie Mide Michelsen
  • Naja Dam Mygind
  • Adam Pena
  • Peter Riis Hansen
  • Henrik Steen Hansen
  • Jens Kastrup
  • Nis Høst
  • Ida Gustafsson
  • Eva Prescott
Vis graf over relationer

BACKGROUND: A significant number of women with angina and no obstructive coronary artery disease (CAD; <50% stenosis) have coronary microvascular dysfunction (CMD) which carries an adverse cardiovascular prognosis. Coronary microvascular function can be evaluated by transthoracic Doppler echocardiography (TTDE) as a coronary flow velocity reserve (CFVR) and by static CT myocardial perfusion (CTP) as a myocardial perfusion reserve (MPR). Whether these methods are correlated is not known. We assessed the correlation between CFVR and MPR and investigated whether women with angina, CMD and no obstructive CAD have reduced MPR compared with asymptomatic women.

METHODS: Static CTP with adenosine-induced vasodilation and TTDE of the left anterior descending artery with dipyridamole-induced vasodilation were successfully performed and analysed in 99 women with stable angina and no obstructive CAD and 33 asymptomatic women with no obstructive CAD. CMD was defined as CFVR < 2.

RESULTS: Correlation between rate-pressure product corrected MPR and CFVR was weak but significant (r = .23; p = .007). MPR was highest among asymptomatic women with normal CFVR (median [interquartile range; IQR] 158 [145-181] %). Symptomatic women with normal CFVR had reduced MPR (148 [134-162] %; age-adjusted p < .001); however, the lowest MPR was found in symptomatic women with CMD (140 [129-164] %; age-adjusted p < .001), independent of cardiovascular risk factors and haemodynamic parameters (p = .017).

CONCLUSION: Women with angina, CMD and no obstructive CAD had markedly diminished MPR compared with asymptomatic women. Correlation between CFVR and MPR was weak, suggesting that CTP and TTDE are not interchangeable for detection of CMD.

OriginalsprogEngelsk
TidsskriftClinical Physiology and Functional Imaging
Vol/bind41
Udgave nummer1
Sider (fra-til)85-94
Antal sider10
ISSN1475-0961
DOI
StatusUdgivet - jan. 2021

ID: 61008858