Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Molecular Phylogenetics of Transmitted Drug Resistance in Newly Diagnosed HIV Type 1 Individuals in Denmark, a Nation-Wide Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Microbial translocation and cardiometabolic risk factors in HIV infection

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Impact of HIV Type 1 DNA Levels on Spontaneous Disease Progression: A Meta-Analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. HIV infection is associated with type 2 diabetes mellitus

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. De novo electrocardiographic abnormalities in persons living with HIV

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. HIV infection is associated with thoracic and abdominal aortic aneurysms: a prospective matched cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Anne Margrethe Audelin
  • Jan Gerstoft
  • Niels Obel
  • Lars Reinhardt Mathiesen
  • Alex Lund Laursen
  • Court Pedersen
  • Henrik Nielsen
  • Janne Jensen
  • Lars Nørregård Nielsen
  • Louise Bruun Jørgensen
  • Claus Nielsen
Vis graf over relationer
Abstract Highly active antiretroviral treatment is compromised by viral resistance mutations. Transmitted drug resistance (TDR) is therefore monitored closely, but follow-up studies of these patients are limited. Virus from 1405 individuals diagnosed with HIV-1 in Denmark between 2001 and 2009 was analyzed for TDR, and molecular-epidemiological links and progression of the infection were described based on data from standardized questionnaires, the prospective Danish HIV Cohort Study, and by phylogenetic analysis. Eighty-five individuals were found to be infected with virus harboring mutations resulting in a prevalence of 6.1%, with no changes over time. The main resistance mutations were nucleoside reverse transcriptase inhibitor (NRTI) mutation 215 revertants, as well as nonnucleoside reverse transcriptase inhibitor (NNRTI) mutation 103N/S and protease inhibitor (PI) mutations 90M and 85V. Phylogenetic analysis confirmed 12 transmission chains involving 37 TDR individuals. Of these 21 were also documented epidemiologically. The virus included in the transmission chain carried similar resistance mutations to the TDR index case, whereas controls chains from index cases without TDR were generally without resistance mutations. We observed no difference in progression of the infection between individuals infected with TDR and individuals infected with wild-type HIV-1. The prevalence of TDR is low in Denmark and transmission of dual-drug-resistant HIV-1 is infrequent. The TDR isolates were shown to originate from local patients failing therapy.
OriginalsprogEngelsk
TidsskriftAIDS Research and Human Retroviruses
Vol/bind27
Udgave nummer12
Sider (fra-til)1283-1290
ISSN0889-2229
DOI
StatusUdgivet - 2011

ID: 32786167