Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
E-pub ahead of print

Molecular imaging of neuroinflammation in patients after mild traumatic brain injury: a longitudinal 123 I-CLINDE single photon emission computed tomography study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Acute endovascular reperfusion treatment in patients with ischaemic stroke and large-vessel occlusion (Denmark 2011–2017)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Disturbed sleep in cluster headache is not the result of transient processes associated with the cluster period

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Early versus later treatment start in multiple sclerosis: a register-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Ictal and interictal electric source imaging in presurgical evaluation: a prospective study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Transcriptome analysis in patients with temporal lobe epilepsy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Patient experience of spinal immobilisation after trauma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Three weeks of SSRI administration enhances the visual perceptual threshold - a randomized placebo-controlled study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND AND PURPOSE: Neuroinflammation has been proposed as part of the pathogenesis of post-concussion symptoms (PCS), but the inflammatory response of the human brain to mild traumatic brain injury (mTBI) remains unknown. We hypothesized that a neuroinflammatory response is present in mTBI at 1-2 weeks post-injury and persists in patients with PCS.

METHODS: We scanned 14 patients with mTBI without signs of structural damage at 1-2 weeks and 3-4 months post-injury and 22 healthy controls once using the single photon emission computed tomography tracer 123 I-CLINDE, which visualizes translocator protein (TSPO), a protein upregulated in active immune cells. PCS was defined as three or more persisting symptoms from the Rivermead Post Concussion Symptoms Questionnaire at 3 months post-injury.

RESULTS: Across brain regions, patients had significantly higher 123 I-CLINDE binding to TSPO than healthy controls, both at 1-2 weeks after the injury in all patients (P = 0.011) and at 3-4 months in the seven patients with PCS (P = 0.006) and in the six patients with good recovery (P = 0.018). When the nine brain regions were tested separately and results were corrected for multiple comparisons, no individual region differed significantly, but all estimated parameters indicated increased 123 I-CLINDE binding to TSPO, ranging from 2% to 19% in all patients at 1-2 weeks, 13% to 27% in patients with PCS at 3-4 months and -9% to 17% in patients with good recovery at 3-4 months.

CONCLUSIONS: Neuroinflammation was present in mTBI at 1-2 weeks post-injury and persisted at 3-4 months post-injury with a tendency to be most pronounced in patients with PCS.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Neurology
ISSN1351-5101
DOI
StatusE-pub ahead of print - 19 apr. 2019

Bibliografisk note

© 2019 EAN.

ID: 57348385