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Mitochondrial haplogroups in patients with rheumatoid arthritis: No association with disease and disease manifestations

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Duhn, Pernille Hurup ; Sode, Jacob ; Hagen, Christian Munch ; Christiansen, Michael ; Locht, Henning. / Mitochondrial haplogroups in patients with rheumatoid arthritis : No association with disease and disease manifestations. I: P L o S One. 2017 ; Bind 12, Nr. 12. s. e0188492.

Bibtex

@article{b8663e22b2154a50baaa92ee94d5a873,
title = "Mitochondrial haplogroups in patients with rheumatoid arthritis: No association with disease and disease manifestations",
abstract = "OBJECTIVE: To describe the distribution of specific mitochondrial DNA (mtDNA) haplogroups (hgs) in a cohort of patients with rheumatoid arthritis (RA).METHODS: Two-hundred nineteen consecutive patients with RA had mtDNA isolated from their blood, sequenced and haplotyped. Patients were diagnosed according to the American College of Rheumatology (ACR)/European league against Rheumatism (EULAR) criteria. Demographic and clinical data were retrieved from the Danish nationwide database (DANBIO). Logistic regression analyses were performed to test for associations.RESULTS: One-hundred eighty-four patients were eligible for analysis. Haplogroup frequencies were: H (n = 88; 47.8{\%}), U (n = 37; 20.1{\%}), T (n = 22; 12.0{\%}), J (n = 16; 8.7{\%}), K (n = 11; 5.9{\%}), HV (n = 6; 3.3{\%}) and V (n = 4; 2.2{\%}). The distribution of individual hgs was identical to the background population. Radiographic erosions were significantly associated with hg clusters JT (OR = 2.37, 95{\%} confidence interval (CI): 1.07-5.53, p = 0.038). Significantly fewer patients from hg cluster JT received biological treatment (OR = 0.17, 95{\%} CI: 0.03-0.87, p = 0.038). Albeit, none of these associations were significant when corrected for multiple tests.CONCLUSION: There was no significant association between mtDNA hgs and presence of RA or disease manifestations. There was an, albeit insignificant, overrepresentation of patients with hg JT among patients with erosive disease; however, slightly fewer patients in the JT group were treated with biological drugs.",
keywords = "Journal Article",
author = "Duhn, {Pernille Hurup} and Jacob Sode and Hagen, {Christian Munch} and Michael Christiansen and Henning Locht",
note = "COPECARE",
year = "2017",
doi = "10.1371/journal.pone.0188492",
language = "English",
volume = "12",
pages = "e0188492",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - Mitochondrial haplogroups in patients with rheumatoid arthritis

T2 - No association with disease and disease manifestations

AU - Duhn, Pernille Hurup

AU - Sode, Jacob

AU - Hagen, Christian Munch

AU - Christiansen, Michael

AU - Locht, Henning

N1 - COPECARE

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: To describe the distribution of specific mitochondrial DNA (mtDNA) haplogroups (hgs) in a cohort of patients with rheumatoid arthritis (RA).METHODS: Two-hundred nineteen consecutive patients with RA had mtDNA isolated from their blood, sequenced and haplotyped. Patients were diagnosed according to the American College of Rheumatology (ACR)/European league against Rheumatism (EULAR) criteria. Demographic and clinical data were retrieved from the Danish nationwide database (DANBIO). Logistic regression analyses were performed to test for associations.RESULTS: One-hundred eighty-four patients were eligible for analysis. Haplogroup frequencies were: H (n = 88; 47.8%), U (n = 37; 20.1%), T (n = 22; 12.0%), J (n = 16; 8.7%), K (n = 11; 5.9%), HV (n = 6; 3.3%) and V (n = 4; 2.2%). The distribution of individual hgs was identical to the background population. Radiographic erosions were significantly associated with hg clusters JT (OR = 2.37, 95% confidence interval (CI): 1.07-5.53, p = 0.038). Significantly fewer patients from hg cluster JT received biological treatment (OR = 0.17, 95% CI: 0.03-0.87, p = 0.038). Albeit, none of these associations were significant when corrected for multiple tests.CONCLUSION: There was no significant association between mtDNA hgs and presence of RA or disease manifestations. There was an, albeit insignificant, overrepresentation of patients with hg JT among patients with erosive disease; however, slightly fewer patients in the JT group were treated with biological drugs.

AB - OBJECTIVE: To describe the distribution of specific mitochondrial DNA (mtDNA) haplogroups (hgs) in a cohort of patients with rheumatoid arthritis (RA).METHODS: Two-hundred nineteen consecutive patients with RA had mtDNA isolated from their blood, sequenced and haplotyped. Patients were diagnosed according to the American College of Rheumatology (ACR)/European league against Rheumatism (EULAR) criteria. Demographic and clinical data were retrieved from the Danish nationwide database (DANBIO). Logistic regression analyses were performed to test for associations.RESULTS: One-hundred eighty-four patients were eligible for analysis. Haplogroup frequencies were: H (n = 88; 47.8%), U (n = 37; 20.1%), T (n = 22; 12.0%), J (n = 16; 8.7%), K (n = 11; 5.9%), HV (n = 6; 3.3%) and V (n = 4; 2.2%). The distribution of individual hgs was identical to the background population. Radiographic erosions were significantly associated with hg clusters JT (OR = 2.37, 95% confidence interval (CI): 1.07-5.53, p = 0.038). Significantly fewer patients from hg cluster JT received biological treatment (OR = 0.17, 95% CI: 0.03-0.87, p = 0.038). Albeit, none of these associations were significant when corrected for multiple tests.CONCLUSION: There was no significant association between mtDNA hgs and presence of RA or disease manifestations. There was an, albeit insignificant, overrepresentation of patients with hg JT among patients with erosive disease; however, slightly fewer patients in the JT group were treated with biological drugs.

KW - Journal Article

U2 - 10.1371/journal.pone.0188492

DO - 10.1371/journal.pone.0188492

M3 - Journal article

VL - 12

SP - e0188492

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 12

ER -

ID: 52411259