Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Milk feed osmolality and adverse events in newborn infants and animals: a systematic review

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cerebral oxygenation and blood flow in term infants during postnatal transition: BabyLux project

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Eight principles for patient-centred and family-centred care for newborns in the neonatal intensive care unit

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The SafeBoosC phase II clinical trial: an analysis of the interventions related with the oximeter readings

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Is near-infrared spectroscopy clinically useful in the preterm infant?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Heel blood sampling in European neonatal intensive care units: compliance with pain management guidelines

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Gut and immune effects of bioactive milk factors in preterm pigs exposed to prenatal inflammation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pathogenesis and biomarkers for necrotizing enterocolitis: Getting any closer?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Zoë-Marie Ellis
  • Hui Shan Grace Tan
  • Nicolas D Embleton
  • Per Torp Sangild
  • Ruurd M van Elburg
Vis graf over relationer

BACKGROUND: High feed osmolality (or osmolarity) is often suggested to be linked with adverse gastrointestinal events in preterm infants.

AIM: To systematically review the literature on milk feed osmolality and adverse gastrointestinal events in newborn and low birthweight infants and animals.

METHODS: MEDLINE, Embase, CAB Abstracts, Current Contents, BIOSIS Previews and SciSearch were searched from inception to May 2018 to identify potentially relevant studies.

INCLUSION CRITERIA: randomised controlled or observational studies of newborn and low birthweight infants or animals investigating the effects of milk-based feeds with different osmolalities. Only full-text, English-language papers were included.

RESULTS: Ten human and six animal studies met the inclusion criteria. Of human studies, seven reported no differences in adverse events with varying feed osmolalities; one reported delayed gastric emptying with feed osmolarity of 539 mOsm/L compared with lower levels; one reported higher necrotising enterocolitis (NEC) incidence with feed osmolarity of 650 mOsm/L compared with 359 mOsm/L; one found higher NEC incidence with the lowest feed osmolality (326 mOsm/kg compared with 385 mOsm/kg). Of animal studies, two reported delayed gastric emptying with feed osmolarity >624 mOsm/L, one reported decreased survival due to dehydration with dietary osmolarities ≥765 mOsmol/L and none reported increased NEC incidence with differing feed osmolalities. No clear mechanisms were found, and diet composition differences limited the interpretations regarding the independent impact of osmolality.

CONCLUSIONS: There is no consistent evidence that differences in feed osmolality in the range 300-500 mOsm/kg are associated with adverse gastrointestinal symptoms in neonates.

OriginalsprogEngelsk
TidsskriftArchives of Disease in Childhood. Fetal and Neonatal Edition
Vol/bind104
Udgave nummer3
Sider (fra-til)F333-F340
ISSN1359-2998
DOI
StatusUdgivet - maj 2019

Bibliografisk note

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

ID: 59422223