Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Migraine and magnetic resonance spectroscopy: a systematic review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Editorial: Remaining diagnostic issues and start of a treatment era for muscle diseases

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The changing course of multiple sclerosis: rising incidence, change in geographic distribution, disease course, and prognosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The influence of lifestyle and gender on cluster headache

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Exercise in muscle disorders: what is our current state?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Update on new muscle glycogenosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The effect of pituitary adenylate cyclase-activating peptide-38 and vasoactive intestinal peptide in cluster headache

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Opening of BKCa channels alters cerebral hemodynamic and causes headache in healthy volunteers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The migraine landscape on YouTube: A review of YouTube as a source of information on migraine

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

PURPOSE OF REVIEW: To present an updated and streamlined overview of the metabolic and biochemical aspect of the migraine pathophysiology based on findings from phosphorous (P) and hydrogen (H) magnetic resonance spectroscopy (MRS) studies.

RECENT FINDINGS: Despite of the variation in the methodology and quality of the MRS migraine studies over time, some results were consistent and reproducible. P-MRS studies suggested reduced availability of neuronal energy and implied a mitochondrial dysfunction in the migraine brain. H-MRS studies reported interictal abnormalities in the excitatory and inhibitory neurotransmitters, glutamate and γ-aminobutyric acid (GABA), suggesting persistent altered excitability in migraine patients. N-Acetylaspartate levels were decreased in migraine, probably due to a mitochondrial dysfunction and abnormal energy metabolism. The reported abnormalities may increase the susceptibility of migraine patients to excitatory stimulation, such as migraine attack triggers.

SUMMARY: Several biochemical aspects of the migraine pathophysiology remain to be elucidated using MRS, such as the migraine attack, correlation to disease severity, and medication efficacy. Nevertheless, to identify a biomarker in migraine, MRS may be a valuable noninvasive technique.

OriginalsprogEngelsk
TidsskriftCurrent Opinion in Neurology
Vol/bind30
Udgave nummer3
Sider (fra-til)246-262
Antal sider17
ISSN1350-7540
DOI
StatusUdgivet - jun. 2017

ID: 52192249