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Migraine

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  1. Prevalence of neck pain in migraine: A systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide in migraine treatment

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  3. Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Brain barriers and their potential role in migraine pathophysiology

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  • Michel D Ferrari
  • Peter J Goadsby
  • Rami Burstein
  • Tobias Kurth
  • Cenk Ayata
  • Andrew Charles
  • Messoud Ashina
  • Arn M J M van den Maagdenberg
  • David W Dodick
Vis graf over relationer

Migraine is a common, chronic, disorder that is typically characterized by recurrent disabling attacks of headache and accompanying symptoms, including aura. The aetiology is multifactorial with rare monogenic variants. Depression, epilepsy, stroke and myocardial infarction are comorbid diseases. Spreading depolarization probably causes aura and possibly also triggers trigeminal sensory activation, the underlying mechanism for the headache. Despite earlier beliefs, vasodilation is only a secondary phenomenon and vasoconstriction is not essential for antimigraine efficacy. Management includes analgesics or NSAIDs for mild attacks, and, for moderate or severe attacks, triptans or 5HT1B/1D receptor agonists. Because of cardiovascular safety concerns, unreliable efficacy and tolerability issues, use of ergots to abort attacks has nearly vanished in most countries. CGRP receptor antagonists (gepants) and lasmiditan, a selective 5HT1F receptor agonist, have emerged as effective acute treatments. Intramuscular onabotulinumtoxinA may be helpful in chronic migraine (migraine on ≥15 days per month) and monoclonal antibodies targeting CGRP or its receptor, as well as two gepants, have proven effective and well tolerated for the preventive treatment of migraine. Several neuromodulation modalities have been approved for acute and/or preventive migraine treatment. The emergence of new treatment targets and therapies illustrates the bright future for migraine management.

OriginalsprogEngelsk
Artikelnummer2
TidsskriftNature reviews. Disease primers
Vol/bind8
Udgave nummer1
Sider (fra-til)2
ISSN2056-676X
DOI
StatusUdgivet - 2022

Bibliografisk note

© 2022. Springer Nature Limited.

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