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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genetics of Coronary Artery Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Mariann Gyöngyösi
  • Wojciech Wojakowski
  • Eliano P Navarese
  • Lemuel À Moye
  • ACCRUE Investigators
  • Jens Kastrup
Vis graf over relationer

In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical outcome. A comprehensive review of the data collection, statistics, and the overall principles of meta-analyses provides further clarification and explanation for this controversy. The advantages and pitfalls of different types of meta-analyses are reviewed here. Each meta-analysis approach has a place when pivotal clinical trials are lacking and sheds light on the magnitude of the treatment in a complex healthcare field.

OriginalsprogEngelsk
TidsskriftCirculation Research
Vol/bind118
Udgave nummer8
Sider (fra-til)1254-63
Antal sider10
ISSN0009-7330
DOI
StatusUdgivet - 15 apr. 2016

ID: 49800423