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Mesenchymal stem cell therapy of acute thermal burns: A systematic review of the effect on inflammation and wound healing

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@article{ccfadbedd0c949bb8832d1f7e0bbabfc,
title = "Mesenchymal stem cell therapy of acute thermal burns: A systematic review of the effect on inflammation and wound healing",
abstract = "AIM: Mesenchymal stem cell (MSC) therapies are emerging as a promising strategy to promote tissue repair, and may extend their utility to burn care. This comprehensive review of the extant literature, evaluated all in vivo studies, to elucidate the potential protective and therapeutic effect of MSCs in acute thermal skin burns.METHODS: PubMed was systematically searched, according to PRISMA guidelines, and all relevant preclinical and clinical studies were included according to pre-specified eligibility criteria.RESULTS: Forty-two studies were included in a qualitative synthesis, of which three were human and 39 were animal studies. The preclinical studies showed that MSCs can significantly reduce inflammation, burn wound progression and accelerate healing rate of acute burns. The underlying mechanisms are complex and not fully understood but paracrine modulators, such as immunomodulatory, antioxidative and trophic factors, seem to play important roles. Allogeneic MSC therapy has proved feasible in humans, and could allow for prompt treatment of acute burns in a clinical setting.CONCLUSION: MSC therapy show positive results, regarding improved burn wound healing and immunologic response. However, most findings are based on small animal studies. Randomized clinical trials are warranted to investigate the regenerative effects in human burns before translating the findings into clinical practice.",
keywords = "Burn therapy, Burns, Cell therapy, Mesenchymal stem cells, Regenerative medicine, Wound healing",
author = "Filip Rangatchew and Peter Vester-Glowinski and Rasmussen, {Bo Sonnich} and Eva Haastrup and Lea Munthe-Fog and Maj-Lis Talman and Christian Bonde and Drzewiecki, {Krzysztof T} and Anne Fischer-Nielsen and Rikke Holmgaard",
note = "Copyright {\textcopyright} 2020 Elsevier Ltd and ISBI. All rights reserved.",
year = "2021",
month = mar,
doi = "10.1016/j.burns.2020.04.012",
language = "English",
volume = "47",
pages = "270--294",
journal = "Burns",
issn = "0305-4179",
publisher = "Pergamon",
number = "2",

}

RIS

TY - JOUR

T1 - Mesenchymal stem cell therapy of acute thermal burns

T2 - A systematic review of the effect on inflammation and wound healing

AU - Rangatchew, Filip

AU - Vester-Glowinski, Peter

AU - Rasmussen, Bo Sonnich

AU - Haastrup, Eva

AU - Munthe-Fog, Lea

AU - Talman, Maj-Lis

AU - Bonde, Christian

AU - Drzewiecki, Krzysztof T

AU - Fischer-Nielsen, Anne

AU - Holmgaard, Rikke

N1 - Copyright © 2020 Elsevier Ltd and ISBI. All rights reserved.

PY - 2021/3

Y1 - 2021/3

N2 - AIM: Mesenchymal stem cell (MSC) therapies are emerging as a promising strategy to promote tissue repair, and may extend their utility to burn care. This comprehensive review of the extant literature, evaluated all in vivo studies, to elucidate the potential protective and therapeutic effect of MSCs in acute thermal skin burns.METHODS: PubMed was systematically searched, according to PRISMA guidelines, and all relevant preclinical and clinical studies were included according to pre-specified eligibility criteria.RESULTS: Forty-two studies were included in a qualitative synthesis, of which three were human and 39 were animal studies. The preclinical studies showed that MSCs can significantly reduce inflammation, burn wound progression and accelerate healing rate of acute burns. The underlying mechanisms are complex and not fully understood but paracrine modulators, such as immunomodulatory, antioxidative and trophic factors, seem to play important roles. Allogeneic MSC therapy has proved feasible in humans, and could allow for prompt treatment of acute burns in a clinical setting.CONCLUSION: MSC therapy show positive results, regarding improved burn wound healing and immunologic response. However, most findings are based on small animal studies. Randomized clinical trials are warranted to investigate the regenerative effects in human burns before translating the findings into clinical practice.

AB - AIM: Mesenchymal stem cell (MSC) therapies are emerging as a promising strategy to promote tissue repair, and may extend their utility to burn care. This comprehensive review of the extant literature, evaluated all in vivo studies, to elucidate the potential protective and therapeutic effect of MSCs in acute thermal skin burns.METHODS: PubMed was systematically searched, according to PRISMA guidelines, and all relevant preclinical and clinical studies were included according to pre-specified eligibility criteria.RESULTS: Forty-two studies were included in a qualitative synthesis, of which three were human and 39 were animal studies. The preclinical studies showed that MSCs can significantly reduce inflammation, burn wound progression and accelerate healing rate of acute burns. The underlying mechanisms are complex and not fully understood but paracrine modulators, such as immunomodulatory, antioxidative and trophic factors, seem to play important roles. Allogeneic MSC therapy has proved feasible in humans, and could allow for prompt treatment of acute burns in a clinical setting.CONCLUSION: MSC therapy show positive results, regarding improved burn wound healing and immunologic response. However, most findings are based on small animal studies. Randomized clinical trials are warranted to investigate the regenerative effects in human burns before translating the findings into clinical practice.

KW - Burn therapy

KW - Burns

KW - Cell therapy

KW - Mesenchymal stem cells

KW - Regenerative medicine

KW - Wound healing

U2 - 10.1016/j.burns.2020.04.012

DO - 10.1016/j.burns.2020.04.012

M3 - Review

C2 - 33218945

VL - 47

SP - 270

EP - 294

JO - Burns

JF - Burns

SN - 0305-4179

IS - 2

ER -

ID: 61660822