Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital

Menstrual Pattern, Reproductive Hormones and Transabdominal 3D Ultrasound in 317 Adolescent Girls

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Corticotroph aggressive pituitary tumours and carcinomas frequently harbour ATRX mutations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Longitudinal Increases in Serum Insulin-like Factor 3 and Testosterone Determined by LC-MS/MS in Pubertal Danish Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Marked increase in incident gynecomastia: a 20-year national registry study, 1998 to 2017

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

CONTEXT: The knowledge of normal variation of reproductive hormones, internal genitalia imaging, and the prevalence of gynecological disorders in adolescent girls is limited.

OBJECTIVE: The study aimed to describe reproductive parameters in postmenarchal girls from the general population including the frequency of oligomenorrhea, polycystic ovary syndrome, and use of hormonal contraception.

DESIGN: The Copenhagen Mother-Child Cohort is a population-based longitudinal birth cohort of 1210 girls born between 1997 and 2002.

SETTING: University hospital.

PARTICIPANTS: A total of 317 girls were included, with a median age of 16.1 years and time since menarche of 2.9 years.

MAIN OUTCOME MEASURE(S): Tanner stage, height, weight, age at menarche, menstrual cycle length and regularity, ovarian/uterine volume, and number of follicles were recorded. Serum concentrations of FSH, LH, anti-Müllerian hormone (AMH), inhibin B, estradiol, testosterone, SHBG, androstenedione, dehydroepiandrosterone sulfate, 17-OH-progesterone, and IGF-1 were measured.

RESULTS: Twenty girls (6.3%) had oligomenorrhea and differed significantly in serum androgens and AMH, age at and time since menarche from girls with regular cycles. Twenty-seven girls were classified with PCOS (8.5%) and had significantly higher 17-OH-progesterone, estradiol, AMH, LH, and age at menarche than the reference group. Girls on oral contraception had significantly higher serum SHBG concentrations and lower serum concentrations of all hormones except AMH and IGF-1. Ovarian follicles 2 to 29.9 mm correlated positively with serum AMH (P < 0.0001).

CONCLUSIONS: Most 16-year-old girls had regular menstrual cycles, normal reproductive hormones, and uterine and ovarian ultrasound. Serum AMH reflected ovarian follicle count and may be a useful biomarker of ovarian reserve.

TidsskriftThe Journal of clinical endocrinology and metabolism
Udgave nummer9
Sider (fra-til)e3257-e3266
Antal sider10
StatusUdgivet - 1 sep. 2020

Bibliografisk note

© Endocrine Society 2020. All rights reserved. For permissions, please e-mail:

ID: 60062152