Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Melanopsin-mediated pupillary responses in bipolar disorder-a cross-sectional pupillometric investigation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Ultraviolet radiation drives mutations in a subset of mucosal melanomas

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Ocular surface microbiota in patients with aqueous tear-deficient dry eye

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The light-induced responses of these ganglion cells can be evaluated by pupillometry. The study aimed to assess the blue light induced pupil constriction in patients with bipolar disorder (BD).

METHODS: We investigated the pupillary responses to blue light by chromatic pupillometry in 31 patients with newly diagnosed bipolar disorder, 22 of their unaffected relatives and 35 healthy controls. Mood state was evaluated by interview-based ratings of depressive symptoms (Hamilton Depression Rating Scale) and (hypo-)manic symptoms (Young Mania Rating Scale).

RESULTS: The ipRGC-mediated pupillary responses did not differ across the three groups, but subgroup analyses showed that patients in remission had reduced ipRGC-mediated responses compared with controls (9%, p = 0.04). Longer illness duration was associated with more pronounced ipRGC-responses (7% increase/10-year illness duration, p = 0.02).

CONCLUSIONS: The ipRGC-mediated pupil response to blue light was reduced in euthymic patients compared with controls and increased with longer disease duration. Longitudinal studies are needed to corroborate these potential associations with illness state and/or progression.

OriginalsprogEngelsk
TidsskriftInternational Journal of Bipolar Disorders
Vol/bind9
Udgave nummer1
Sider (fra-til)7
ISSN2194-7511
DOI
StatusUdgivet - 1 mar. 2021

ID: 64185483