Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Measurement and Reproducibility of Preserved Ellipsoid Zone Area and Preserved Retinal Pigment Epithelium Area in Eyes With Choroideremia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The Natural History of Inherited Retinal Dystrophy Due to Biallelic Mutations in the RPE65 Gene

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Orbital Lymphoma - An International Multicenter Retrospective Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. THE SMALL FATAL CHOROIDAL MELANOMA STUDY A Survey by the European Ophthalmic Oncology Group

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Primary Secretory Carcinoma of the Lacrimal Gland: Report of a New Entity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Lymphoma of the Eyelid - An International Multicenter Retrospective Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Central serous chorioretinopathy: Towards an evidence-based treatment guideline

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Macular spatial distribution of preserved autofluorescence in patients with choroideremia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Small Hard Macular Drusen and Associations in 11- to 12-Year-Old Children in the Copenhagen Child Cohort 2000 Eye Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Amir H Hariri
  • Swetha B Velaga
  • Aniz Girach
  • Michael S Ip
  • Phuc V Le
  • Byron L Lam
  • M Dominik Fischer
  • Eeva-Marja Sankila
  • Mark E Pennesi
  • Frank G Holz
  • Robert E MacLaren
  • David G Birch
  • Carel B Hoyng
  • Ian M MacDonald
  • Graeme C Black
  • Stephen H Tsang
  • Neil M Bressler
  • Michael Larsen
  • Michael B Gorin
  • Andrew R Webster
  • SriniVas R Sadda
  • Natural History of the Progression of Choroideremia (NIGHT) Study Group
Vis graf over relationer

PURPOSE: To identify valid and reproducible methods for quantifying anatomic outcome measures for eyes with choroideremia (CHM) in clinical trials.

DESIGN: Reliability analysis study.

METHODS: In this multicenter study, patients with confirmed genetic diagnosis of CHM were enrolled. All cases underwent spectral-domain optical coherence tomography (SDOCT) and fundus autofluorescence (FAF) imaging. Two graders independently delineated boundaries of preserved autofluorescence (PAF) and preserved ellipsoid zone (EZ) on FAF and OCT images, respectively. The results of the 2 independent gradings of both FAF and OCT images were compared to assess the reproducibility of the grading methods.

RESULTS: A total of 148 eyes from 75 cases were included. In 21% of eyes PAF and in 43% of eyes preserved EZ had extended beyond the image capture area. After exclusion of these eyes and low-quality images, 114 FAF and 77 OCT images were graded. The mean PAF areas from 2 independent gradings were 3.720 ± 3.340 mm2and 3.692 ± 3.253 mm2, respectively. Intraclass correlation coefficient (ICC) for these gradings was 0.996. The mean preserved EZ areas from 2 independent gradings were 2.746 ± 2.319 mm2and 2.858 ± 2.446 mm2, respectively. ICC for these gradings was 0.991.

CONCLUSIONS: Quantifying preserved retinal pigment epithelium and EZ areas on FAF and OCT images, respectively, in CHM patients is highly reproducible. These variables would be potential anatomic outcome measures for CHM clinical trials and could be studied and tracked longitudinally in choroideremia.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Ophthalmology
Vol/bind179
Sider (fra-til)110-117
Antal sider8
ISSN0002-9394
DOI
StatusUdgivet - jul. 2017

ID: 52802181