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Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; A prospective cohort study

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Jøhnk, Camilla ; Høst, Arne ; Husby, Steffen ; Schoeters, Greet ; Timmermann, Clara Amalie Gade ; Kyhl, Henriette Boye ; Beck, Iben Have ; Andersson, Anna Maria ; Frederiksen, Hanne ; Jensen, Tina Kold. / Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; A prospective cohort study. I: Environmental Health: A Global Access Science Source. 2020 ; Bind 19, Nr. 1. s. 32.

Bibtex

@article{24340355534d402bba226cf01fe9846c,
title = "Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; A prospective cohort study",
abstract = "Background: Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis in offspring aged 5 years. Methods: From 552 pregnant women in the Odense Child Cohort, we quantified urinary concentrations of 12 phthalate metabolites in third trimester. We assessed asthma, rhinitis and eczema in their offspring at age 5 years with a questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC), and conducted logistic regression adjusting for relevant confounders. Results: 7.4% of the children had asthma, 11.7% eczema and 9.2% rhinitis. Phthalate exposure was low compared to previous cohorts. No significant associations between prenatal phthalate exposure and asthma were found. Odds ratios (ORs) of child rhinitis with a doubling in ςDiNPm and di-2-ethylhexyl phthalate metabolite (ςDEHPm) concentrations were, respectively, 1.15 (95% confidence interval (CI) 0.97,1.36) and 1.21 (CI 0.93,1.58). The OR of eczema when doubling ςDiNPm was 1.24 (CI 1.00,1.55), whereas the OR of using medicine against eczema when doubling a di-ethyl phthalate (DEP) metabolite was 0.81 (CI 0.68,0.96). Conclusion: The lack of association between maternal phthalate exposure and asthma in the offspring may be due to low exposure and difficulties in determining asthma in 5-year-olds. The higher odds of rhinitis may raise public concern but further research in larger cohorts of older children is warranted.",
keywords = "Allergic rhinitis, Asthma, Endocrine disrupting chemicals, Phthalate exposure, sEczema, Environmental Pollutants/adverse effects, Prevalence, Prospective Studies, Humans, Asthma/chemically induced, Rhinitis/chemically induced, Male, Phthalic Acids/adverse effects, Pregnancy Trimester, Third, Pregnancy, Denmark/epidemiology, Prenatal Exposure Delayed Effects/chemically induced, Eczema/chemically induced, Female, Plasticizers/adverse effects, Maternal Exposure/adverse effects, Child",
author = "Camilla J{\o}hnk and Arne H{\o}st and Steffen Husby and Greet Schoeters and Timmermann, {Clara Amalie Gade} and Kyhl, {Henriette Boye} and Beck, {Iben Have} and Andersson, {Anna Maria} and Hanne Frederiksen and Jensen, {Tina Kold}",
year = "2020",
month = mar,
day = "13",
doi = "10.1186/s12940-020-00586-x",
language = "English",
volume = "19",
pages = "32",
journal = "Environmental Health: A Global Access Science Source",
issn = "1476-069X",
publisher = "BioMed Central Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; A prospective cohort study

AU - Jøhnk, Camilla

AU - Høst, Arne

AU - Husby, Steffen

AU - Schoeters, Greet

AU - Timmermann, Clara Amalie Gade

AU - Kyhl, Henriette Boye

AU - Beck, Iben Have

AU - Andersson, Anna Maria

AU - Frederiksen, Hanne

AU - Jensen, Tina Kold

PY - 2020/3/13

Y1 - 2020/3/13

N2 - Background: Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis in offspring aged 5 years. Methods: From 552 pregnant women in the Odense Child Cohort, we quantified urinary concentrations of 12 phthalate metabolites in third trimester. We assessed asthma, rhinitis and eczema in their offspring at age 5 years with a questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC), and conducted logistic regression adjusting for relevant confounders. Results: 7.4% of the children had asthma, 11.7% eczema and 9.2% rhinitis. Phthalate exposure was low compared to previous cohorts. No significant associations between prenatal phthalate exposure and asthma were found. Odds ratios (ORs) of child rhinitis with a doubling in ςDiNPm and di-2-ethylhexyl phthalate metabolite (ςDEHPm) concentrations were, respectively, 1.15 (95% confidence interval (CI) 0.97,1.36) and 1.21 (CI 0.93,1.58). The OR of eczema when doubling ςDiNPm was 1.24 (CI 1.00,1.55), whereas the OR of using medicine against eczema when doubling a di-ethyl phthalate (DEP) metabolite was 0.81 (CI 0.68,0.96). Conclusion: The lack of association between maternal phthalate exposure and asthma in the offspring may be due to low exposure and difficulties in determining asthma in 5-year-olds. The higher odds of rhinitis may raise public concern but further research in larger cohorts of older children is warranted.

AB - Background: Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis in offspring aged 5 years. Methods: From 552 pregnant women in the Odense Child Cohort, we quantified urinary concentrations of 12 phthalate metabolites in third trimester. We assessed asthma, rhinitis and eczema in their offspring at age 5 years with a questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC), and conducted logistic regression adjusting for relevant confounders. Results: 7.4% of the children had asthma, 11.7% eczema and 9.2% rhinitis. Phthalate exposure was low compared to previous cohorts. No significant associations between prenatal phthalate exposure and asthma were found. Odds ratios (ORs) of child rhinitis with a doubling in ςDiNPm and di-2-ethylhexyl phthalate metabolite (ςDEHPm) concentrations were, respectively, 1.15 (95% confidence interval (CI) 0.97,1.36) and 1.21 (CI 0.93,1.58). The OR of eczema when doubling ςDiNPm was 1.24 (CI 1.00,1.55), whereas the OR of using medicine against eczema when doubling a di-ethyl phthalate (DEP) metabolite was 0.81 (CI 0.68,0.96). Conclusion: The lack of association between maternal phthalate exposure and asthma in the offspring may be due to low exposure and difficulties in determining asthma in 5-year-olds. The higher odds of rhinitis may raise public concern but further research in larger cohorts of older children is warranted.

KW - Allergic rhinitis

KW - Asthma

KW - Endocrine disrupting chemicals

KW - Phthalate exposure

KW - sEczema

KW - Environmental Pollutants/adverse effects

KW - Prevalence

KW - Prospective Studies

KW - Humans

KW - Asthma/chemically induced

KW - Rhinitis/chemically induced

KW - Male

KW - Phthalic Acids/adverse effects

KW - Pregnancy Trimester, Third

KW - Pregnancy

KW - Denmark/epidemiology

KW - Prenatal Exposure Delayed Effects/chemically induced

KW - Eczema/chemically induced

KW - Female

KW - Plasticizers/adverse effects

KW - Maternal Exposure/adverse effects

KW - Child

UR - http://www.scopus.com/inward/record.url?scp=85081981690&partnerID=8YFLogxK

U2 - 10.1186/s12940-020-00586-x

DO - 10.1186/s12940-020-00586-x

M3 - Journal article

C2 - 32169083

AN - SCOPUS:85081981690

VL - 19

SP - 32

JO - Environmental Health: A Global Access Science Source

JF - Environmental Health: A Global Access Science Source

SN - 1476-069X

IS - 1

M1 - 32

ER -

ID: 59732605