Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Management of chronic rhinosinusitis with nasal polyps and coexisting asthma: A systematic review

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Sinus bacteriology in patients with cystic fibrosis or primary ciliary dyskinesia: A systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Asthma in ear, nose, and throat primary care patients with chronic rhinosinusitis with nasal polyps

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Increased endothelin 1 type B receptors in nasal lesions of patients with granulomatosis with polyangiitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Propofol sedation in Drug Induced Sedation Endoscopy without an anaesthesiologist â€" a study of safety and feasibility

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Transoral robotkirurgi til behandling af hoved-hals-kræft

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and asthma are strongly associated, and patients suffering from both diseases are often difficult to treat. However, no guidelines about the management of patients with CRS and coexisting asthma exist.

OBJECTIVE: The purpose of this systematic review was to evaluate the management of CRSwNP and coexisting asthma.

METHODS: We systematically searched electronic databases and included clinical trials in which the clinical outcomes after medical or surgical treatment of patients with CRSwNP and asthma were assessed. The strength of the evidence for each outcome was graded on the basis of study quality and consistency in findings.

RESULTS: We included seven trials in which the effect of montelukast, omalizumab, erythromycin, and functional endoscopic sinus surgery (FESS) were studied in 317 adults with CRSwNP and asthma. All the interventions improved the majority of subjective and objective nasal outcomes significantly. However, few studies found significant effects on pulmonary function tests. The strength of the evidence was low overall.

CONCLUSION: Both FESS and medical interventions with systemic anti-inflammatory drugs improved nasal outcomes, although their efficacy in relation to the lower airways remains unclear. A low number of studies met inclusion criteria for this systematic review, which emphasizes the need for high-quality trials to explore the treatment of patients with CRSwNP and coexisting asthma.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Rhinology & Allergy
Vol/bind29
Udgave nummer3
Sider (fra-til)193-201
Antal sider9
ISSN1945-8924
DOI
StatusUdgivet - 16 maj 2015

ID: 46001215