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Rigshospitalet - en del af Københavns Universitetshospital
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Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

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  • Valentina Silvestri
  • Daniel Barrowdale
  • Anna Marie Mulligan
  • Susan L Neuhausen
  • Stephen Fox
  • Beth Y Karlan
  • Gillian Mitchell
  • Paul James
  • Darcy L Thull
  • Kristin K Zorn
  • Natalie J Carter
  • Katherine L Nathanson
  • Susan M Domchek
  • Timothy R Rebbeck
  • Susan J Ramus
  • Robert L Nussbaum
  • Olufunmilayo I Olopade
  • Johanna Rantala
  • Sook-Yee Yoon
  • Maria A Caligo
  • Laura Spugnesi
  • Anders Bojesen
  • Inge Sokilde Pedersen
  • Mads Thomassen
  • Uffe Birk Jensen
  • Amanda Ewart Toland
  • Leigha Senter
  • Irene L Andrulis
  • Gord Glendon
  • Peter J Hulick
  • Evgeny N Imyanitov
  • Mark H Greene
  • Phuong L Mai
  • Christian F Singer
  • Christine Rappaport-Fuerhauser
  • Gero Kramer
  • Joseph Vijai
  • Kenneth Offit
  • Mark Robson
  • Anne Lincoln
  • Lauren Jacobs
  • Eva Machackova
  • Lenka Foretova
  • Marie Navratilova
  • Petra Vasickova
  • Fergus J Couch
  • Emily Hallberg
  • Anne-Marie Gerdes
  • Bent Ejlertsen
  • Thomas V O Hansen
  • kConFab Investigators
Vis graf over relationer

BACKGROUND: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs).

METHODS: We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database.

RESULTS: Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10(-5)) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor-positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15-21.80] and progesterone receptor-positive (OR 5.04; 95 % CI 3.17-8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10(-12)).

CONCLUSIONS: On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management.

OriginalsprogEngelsk
TidsskriftBreast Cancer Research
Vol/bind18
Udgave nummer1
Sider (fra-til)15
ISSN1465-542X
DOI
StatusUdgivet - 9 feb. 2016

ID: 49236383