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Macular spatial distribution of preserved autofluorescence in patients with choroideremia

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Hariri, AH, Ip, MS, Girach, A, Lam, BL, Fischer, MD, Sankila, E-M, Pennesi, ME, Holz, FG, Maclaren, RE, Birch, DG, Hoyng, CB, MacDonald, IM, Black, GC, Tsang, SH, Bressler, NM, Stepien, KE, Larsen, M, Gorin, MB, Meunier, I, Webster, AR & Sadda, S 2019, 'Macular spatial distribution of preserved autofluorescence in patients with choroideremia' The British journal of ophthalmology, bind 103, nr. 7, s. 933-937. https://doi.org/10.1136/bjophthalmol-2018-312620

APA

Hariri, A. H., Ip, M. S., Girach, A., Lam, B. L., Fischer, M. D., Sankila, E-M., ... Sadda, S. (2019). Macular spatial distribution of preserved autofluorescence in patients with choroideremia. The British journal of ophthalmology, 103(7), 933-937. https://doi.org/10.1136/bjophthalmol-2018-312620

CBE

Hariri AH, Ip MS, Girach A, Lam BL, Fischer MD, Sankila E-M, Pennesi ME, Holz FG, Maclaren RE, Birch DG, Hoyng CB, MacDonald IM, Black GC, Tsang SH, Bressler NM, Stepien KE, Larsen M, Gorin MB, Meunier I, Webster AR, Sadda S. 2019. Macular spatial distribution of preserved autofluorescence in patients with choroideremia. The British journal of ophthalmology. 103(7):933-937. https://doi.org/10.1136/bjophthalmol-2018-312620

MLA

Vancouver

Author

Hariri, Amir H ; Ip, Michael S ; Girach, Aniz ; Lam, Byron L ; Fischer, M Dominik ; Sankila, Eeva-Marja ; Pennesi, Mark Edward ; Holz, Frank G ; Maclaren, Robert E ; Birch, David G ; Hoyng, Carel B ; MacDonald, Ian M ; Black, Graeme C ; Tsang, Stephen H ; Bressler, Neil M ; Stepien, Kimberly E ; Larsen, Michael ; Gorin, Michael B ; Meunier, Isabelle ; Webster, Andrew R ; Sadda, SriniVas. / Macular spatial distribution of preserved autofluorescence in patients with choroideremia. I: The British journal of ophthalmology. 2019 ; Bind 103, Nr. 7. s. 933-937.

Bibtex

@article{4506515900194a1d83518b3f96032f2a,
title = "Macular spatial distribution of preserved autofluorescence in patients with choroideremia",
abstract = "BACKGROUND/AIMS: To better understand the pattern of degeneration progression in cases with choroideremia.METHODS: A cohort of genotypically confirmed choroideremia cases who underwent optical coherence tomography (OCT) and fundus autofluorescence (FAF) imaging was studied. Using HEYEX review software, the foveal centre was marked on FAF images under guidance of corresponding OCT images, followed by application of an ETDRS grid. The boundaries of preserved autofluorescence (AF) were manually segmented in each individual ETDRS subfield. The regional distribution of preserved AF was assessed by comparing its area among the various subfields.RESULTS: A total of 168 eyes from 84 choroideremia cases were enrolled. There was a statistically significant difference in the amount of preserved AF area between inner subfields as determined by one-way analysis of variance (F (3,668)=9.997, p<0.001) and also between outer subfields (F (3,668)=8.348, p<0.001). A Tukey posthoc test revealed that the preserved AF area in the nasal subfields in both the inner and outer subfields was significantly smaller compared with analogue subfields.CONCLUSION: The asymmetric spatial distribution of preserved AF in choroideremia (corresponding to the stellate shaped nature of these regions) suggests that the progression of degeneration has directional preference.",
keywords = "choroideremia, ellipsoid zone, fundus autofluorescence, optical coherence tomography, preserved autofluorescence, retinal pigment epithelium",
author = "Hariri, {Amir H} and Ip, {Michael S} and Aniz Girach and Lam, {Byron L} and Fischer, {M Dominik} and Eeva-Marja Sankila and Pennesi, {Mark Edward} and Holz, {Frank G} and Maclaren, {Robert E} and Birch, {David G} and Hoyng, {Carel B} and MacDonald, {Ian M} and Black, {Graeme C} and Tsang, {Stephen H} and Bressler, {Neil M} and Stepien, {Kimberly E} and Michael Larsen and Gorin, {Michael B} and Isabelle Meunier and Webster, {Andrew R} and SriniVas Sadda",
note = "{\circledC} Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
month = "7",
doi = "10.1136/bjophthalmol-2018-312620",
language = "English",
volume = "103",
pages = "933--937",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "B M J Group",
number = "7",

}

RIS

TY - JOUR

T1 - Macular spatial distribution of preserved autofluorescence in patients with choroideremia

AU - Hariri, Amir H

AU - Ip, Michael S

AU - Girach, Aniz

AU - Lam, Byron L

AU - Fischer, M Dominik

AU - Sankila, Eeva-Marja

AU - Pennesi, Mark Edward

AU - Holz, Frank G

AU - Maclaren, Robert E

AU - Birch, David G

AU - Hoyng, Carel B

AU - MacDonald, Ian M

AU - Black, Graeme C

AU - Tsang, Stephen H

AU - Bressler, Neil M

AU - Stepien, Kimberly E

AU - Larsen, Michael

AU - Gorin, Michael B

AU - Meunier, Isabelle

AU - Webster, Andrew R

AU - Sadda, SriniVas

N1 - © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019/7

Y1 - 2019/7

N2 - BACKGROUND/AIMS: To better understand the pattern of degeneration progression in cases with choroideremia.METHODS: A cohort of genotypically confirmed choroideremia cases who underwent optical coherence tomography (OCT) and fundus autofluorescence (FAF) imaging was studied. Using HEYEX review software, the foveal centre was marked on FAF images under guidance of corresponding OCT images, followed by application of an ETDRS grid. The boundaries of preserved autofluorescence (AF) were manually segmented in each individual ETDRS subfield. The regional distribution of preserved AF was assessed by comparing its area among the various subfields.RESULTS: A total of 168 eyes from 84 choroideremia cases were enrolled. There was a statistically significant difference in the amount of preserved AF area between inner subfields as determined by one-way analysis of variance (F (3,668)=9.997, p<0.001) and also between outer subfields (F (3,668)=8.348, p<0.001). A Tukey posthoc test revealed that the preserved AF area in the nasal subfields in both the inner and outer subfields was significantly smaller compared with analogue subfields.CONCLUSION: The asymmetric spatial distribution of preserved AF in choroideremia (corresponding to the stellate shaped nature of these regions) suggests that the progression of degeneration has directional preference.

AB - BACKGROUND/AIMS: To better understand the pattern of degeneration progression in cases with choroideremia.METHODS: A cohort of genotypically confirmed choroideremia cases who underwent optical coherence tomography (OCT) and fundus autofluorescence (FAF) imaging was studied. Using HEYEX review software, the foveal centre was marked on FAF images under guidance of corresponding OCT images, followed by application of an ETDRS grid. The boundaries of preserved autofluorescence (AF) were manually segmented in each individual ETDRS subfield. The regional distribution of preserved AF was assessed by comparing its area among the various subfields.RESULTS: A total of 168 eyes from 84 choroideremia cases were enrolled. There was a statistically significant difference in the amount of preserved AF area between inner subfields as determined by one-way analysis of variance (F (3,668)=9.997, p<0.001) and also between outer subfields (F (3,668)=8.348, p<0.001). A Tukey posthoc test revealed that the preserved AF area in the nasal subfields in both the inner and outer subfields was significantly smaller compared with analogue subfields.CONCLUSION: The asymmetric spatial distribution of preserved AF in choroideremia (corresponding to the stellate shaped nature of these regions) suggests that the progression of degeneration has directional preference.

KW - choroideremia

KW - ellipsoid zone

KW - fundus autofluorescence

KW - optical coherence tomography

KW - preserved autofluorescence

KW - retinal pigment epithelium

U2 - 10.1136/bjophthalmol-2018-312620

DO - 10.1136/bjophthalmol-2018-312620

M3 - Journal article

VL - 103

SP - 933

EP - 937

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 7

ER -

ID: 56583982