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Rigshospitalet - en del af Københavns Universitetshospital
E-pub ahead of print

Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Kristoffer Grundtvig Skaarup
  • Mats Christian Højbjerg Lassen
  • Caroline Espersen
  • Jannie Nørgaard Lind
  • Niklas Dyrby Johansen
  • Morten Sengeløv
  • Alia Saed Alhakak
  • Anne Bjerg Nielsen
  • Kirstine Ravnkilde
  • Raphael Hauser
  • Liv Borum Schöps
  • Eva Holt
  • Henning Bundgaard
  • Christian Hassager
  • Reza Jabbari
  • Jørn Carlsen
  • Ole Kirk
  • Uffe Bodtger
  • Matias Greve Lindholm
  • Lothar Wiese
  • Ole Peter Kristiansen
  • Emil Schwarz Walsted
  • Olav Wendelboe Nielsen
  • Birgitte Lindegaard
  • Niels Tønder
  • Klaus Nielsen Jeschke
  • Charlotte Suppli Ulrik
  • Morten Lamberts
  • Pradeesh Sivapalan
  • Jannik Pallisgaard
  • Gunnar Gislason
  • Kasper Iversen
  • Jens Ulrik Stæhr Jensen
  • Morten Schou
  • Søren Helbo Skaarup
  • Elke Platz
  • Tor Biering-Sørensen
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PURPOSE: Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE).

METHODS: A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores).

RESULTS: Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses.

CONCLUSION: In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. CLINICALTRIALS.

GOV ID: NCT04377035.

OriginalsprogEngelsk
TidsskriftJournal of ultrasound
ISSN1876-7931
DOI
StatusE-pub ahead of print - 2 jul. 2021

ID: 66565591