Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Lower-Grade Gliomas: An Epidemiological Voxel-Based Analysis of Location and Proximity to Eloquent Regions

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Immune Cell Profiling of Peripheral Blood as Signature for Response During Checkpoint Inhibition Across Cancer Types

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. HER2 Positivity in Histological Subtypes of Salivary Gland Carcinoma: A Systematic Review and Meta-Analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Systemic Immune Modulation in Gliomas: Prognostic Value of Plasma IL-6, YKL-40, and Genetic Variation in YKL-40

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Proposal of a new grading system for meningioma resection: the Copenhagen Protocol

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Variations in the management of diffuse low-grade gliomas-A Scandinavian multicenter study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Burr hole craniostomy versus minicraniotomy in chronic subdural hematoma: a comparative cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Tomás Gómez Vecchio
  • Alice Neimantaite
  • Alba Corell
  • Jiri Bartek
  • Margret Jensdottir
  • Ingerid Reinertsen
  • Ole Solheim
  • Asgeir S Jakola
Vis graf over relationer

Background: Glioma is the most common intra-axial tumor, and its location relative to critical areas of the brain is important for treatment decision-making. Studies often report tumor location based on anatomical taxonomy alone since the estimation of eloquent regions requires considerable knowledge of functional neuroanatomy and is, to some degree, a subjective measure. An unbiased and reproducible method to determine tumor location and eloquence is desirable, both for clinical use and for research purposes.

Objective: To report on a voxel-based method for assessing anatomical distribution and proximity to eloquent regions in diffuse lower-grade gliomas (World Health Organization grades 2 and 3).

Methods: A multi-institutional population-based dataset of adult patients (≥18 years) histologically diagnosed with lower-grade glioma was analyzed. Tumor segmentations were registered to a standardized space where two anatomical atlases were used to perform a voxel-based comparison of the proximity of segmentations to brain regions of traditional clinical interest.

Results: Exploring the differences between patients with oligodendrogliomas, isocitrate dehydrogenase (IDH) mutated astrocytomas, and patients with IDH wild-type astrocytomas, we found that the latter were older, more often had lower Karnofsky performance status, and that these tumors were more often found in the proximity of eloquent regions. Eloquent regions are found slightly more frequently in the proximity of IDH-mutated astrocytomas compared to oligodendrogliomas. The regions included in our voxel-based definition of eloquence showed a high degree of association with performing biopsy compared to resection.

Conclusion: We present a simple, robust, unbiased, and clinically relevant method for assessing tumor location and eloquence in lower-grade gliomas.

OriginalsprogEngelsk
Artikelnummer748229
TidsskriftFrontiers in Oncology
Vol/bind11
Sider (fra-til)748229
ISSN2234-943X
DOI
StatusUdgivet - 2021

Bibliografisk note

Copyright © 2021 Gómez Vecchio, Neimantaite, Corell, Bartek, Jensdottir, Reinertsen, Solheim and Jakola.

ID: 68244028