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Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?

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Here we imaged serotonin 2A receptor (5-HT2AR) binding in a very rare population of monozygotic twins discordant for schizophrenia to provide insight into trait and state components in brain 5-HT2AR patterns. In four twin pairs not medicated with drugs that target 5-HT2AR, frontal 5-HT2AR binding was consistently lower (33%) in schizophrenic- relative to their healthy co-twins. Our results strongly imply low frontal 5-HT2AR availability as a state feature of schizophrenia. If replicated, ideally in a larger sample also including dizygotic twin pairs and drug-naïve patients, this finding critically advance our understanding of the complex pathophysiology of schizophrenia.

TidsskriftEuropean Neuropsychopharmacology
Udgave nummer7
Sider (fra-til)1248-1250
Antal sider3
StatusUdgivet - jul. 2016

ID: 46462134