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Rigshospitalet - en del af Københavns Universitetshospital
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Long-term air pollution and road traffic noise exposure and COPD: the Danish Nurse Cohort

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  • Shuo Liu
  • Marie Pedersen
  • Jeanette Jørgensen
  • Heresh Amini
  • Thomas Cole-Hunter
  • Amar Mehta
  • Rina So
  • Laust Mortensen
  • Rudi Westendorp
  • Steffen Loft
  • Elvira Bräuner
  • Matthias Ketzel
  • Ole Hertel
  • Jørgen Brandt
  • Steen Jensen
  • Jesper Christensen
  • Torben Sigsgaard
  • Camilla Geels
  • Linda Frohn
  • Maja Brboric
  • Jelena Radonic
  • Maja Sekulic
  • Klaus Bønnelykke
  • Claus Backalarz
  • Mette Kildevæld Simonsen
  • Zorana Andersen
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BACKGROUND: While air pollution has been linked to the development of chronic obstructive pulmonary disease (COPD), evidence on the role of environmental noise is just emerging. We examined the associations of long-term exposure to air pollution and road traffic noise with COPD incidence.

METHODS: We defined COPD incidence for 24 538 female nurses from the Danish Nurse Cohort (age >44 years) as the first hospital contact between baseline (1993 or 1999) and 2015. We estimated residential annual mean concentrations of particulate matter with an aerodynamic diameter <2.5 µm (PM2.5) since 1990 and nitrogen dioxide (NO2) since 1970 using the Danish Eulerian Hemispheric Model/Urban Background Model/Air Geographic Information System modelling system, and road traffic noise (Lden) since 1970 using the Nord2000 model. Time-varying Cox regression models were applied to assess the associations of air pollution and road traffic noise with COPD incidence.

RESULTS: 977 nurses developed COPD during a mean of 18.6 years' follow-up. We observed associations with COPD for all three exposures with HRs and 95% CIs of 1.19 (1.01-1.41) per 6.26 µg·m-3 for PM2.5, 1.13 (1.05-1.20) per 8.19 µg·m-3 for NO2 and 1.15 (1.06-1.25) per 10 dB for Lden. Associations with NO2 and Lden attenuated slightly after mutual adjustment, but were robust to adjustment for PM2.5. Associations with PM2.5 were attenuated to null after adjustment for either NO2 or Lden. No potential interaction effect was observed between air pollutants and noise.

CONCLUSION: Long-term exposure to air pollution, especially traffic-related NO2, and to road traffic noise were independently associated with COPD.

OriginalsprogEngelsk
Artikelnummer2004594
TidsskriftEuropean Respiratory Journal
Vol/bind58
Udgave nummer6
ISSN0903-1936
DOI
StatusUdgivet - dec. 2021

ID: 65784349