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Late Malignant Transformation of a Vestibular Schwannoma without Association to NFII or Radiotherapy

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@conference{43139f8900784d1da5970539cc8af899,
title = "Late Malignant Transformation of a Vestibular Schwannoma without Association to NFII or Radiotherapy",
abstract = "Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.",
author = "Asma Bashir and Lars Poulsgaard and Helle Broholm and K{\aa}re Fugleholm",
year = "2016",
doi = "10.3171/2015.6.JNS1544",
language = "English",

}

RIS

TY - ABST

T1 - Late Malignant Transformation of a Vestibular Schwannoma without Association to NFII or Radiotherapy

AU - Bashir, Asma

AU - Poulsgaard, Lars

AU - Broholm, Helle

AU - Fugleholm, Kåre

PY - 2016

Y1 - 2016

N2 - Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.

AB - Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.

U2 - 10.3171/2015.6.JNS1544

DO - 10.3171/2015.6.JNS1544

M3 - Conference abstract for conference

ER -

ID: 49822564