Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Lactoferrin in cerebrospinal fluid and saliva is not a diagnostic biomarker for Alzheimer's disease in a mixed memory clinic population

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Atrial fibrillation burden and cognitive decline in elderly patients undergoing continuous monitoring

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Comparing a Single Clinician Versus a Multidisciplinary Consensus Conference Approach for Dementia Diagnostics

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Imaging of the Serotonin System: Radiotracers and Applications in Memory Disorders

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiUndervisning

Vis graf over relationer

BACKGROUND: The pathological changes in Alzheimer's Disease (AD) and other neurodegenerative disorders begin decades prior to their clinical expression. However, the clinical diagnosis of neurodegenerative dementias is not straightforward. Lactoferrin is an iron-binding, antimicrobial glycoprotein with a plethora of functions, including acting as an important immune modulator and by having a bacteriocidic effect. Two previous studies indicated that salivary lactoferrin could differentiate between neurodegenerative dementias.

METHODS: A total of 222 cerebrospinal fluid (CSF) and saliva samples from a consecutive, mixed memory clinic population were analysed for lactoferrin. In addition, the association between lactoferrin in CSF and saliva and the concentration of tau, phosphorylated tau (p-tau) and amyloid 1-42 (Aβ42) in CSF were addressed.

FINDINGS: CSF lactoferrin was assessed for the first time in a cohort of patients with neurodegenerative dementias. No significant differences were found in the levels of CSF or saliva lactoferrin between the diagnostic groups. In addition, no significant relationships were found between lactoferrin levels and tau, p-tau and Aβ42, respectively.

INTERPRETATION: Neither CSF nor saliva lactoferrin could differentiate between neurodegenerative dementias in this study.

OriginalsprogEngelsk
Artikelnummer103361
TidsskriftEBioMedicine
Vol/bind67
Sider (fra-til)103361
DOI
StatusUdgivet - maj 2021

Bibliografisk note

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

ID: 68395984