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Labyrinthitis Ossificans: On the Mechanism of Perilabyrinthine Bone Remodeling

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@article{9ed60a9bbae143859a0b3d8843bd8edf,
title = "Labyrinthitis Ossificans: On the Mechanism of Perilabyrinthine Bone Remodeling",
abstract = "INTRODUCTION: It has been suggested that remodeling of the otic capsule is highly suppressed by the action of anti-resorptive signals emanating from structures of the inner ear space. Labyrinthitis ossificans (LO) is a severe complication to bacterial meningitis and is characterized by destruction of inner ear structures by the formation of new bone. The aim of this study was to explore the impact of LO on bone remodeling of the otic capsule.MATERIAL AND METHODS: In 11 human temporal bones with extensive LO and 10 control specimens, the degree of bone remodeling was explored indirectly by estimating the viability of osteocytes in perilabyrinthine bone and the mastoid.RESULTS: The viability of osteocytes was significantly lower in the perilabyrinthine bone compared to the mastoid in both groups. However, the loss of perilabyrinthine osteocytes was the same in the 2 groups, and the presence of cartilage remnants appeared to be the same.CONCLUSION: This study indicates that the factors affecting bone remodeling of the otic capsule and the degeneration of osteocytes are not altered by wholesale destruction of inner ear soft tissue and its replacement by bone. Therefore, alternative mechanisms may be implicated in the suppression of capsular bone remodeling.",
keywords = "Aged, Aged, 80 and over, Anatomy, Regional, Bone Remodeling, Ear, Inner, Female, Humans, Labyrinthitis, Male, Mastoid, Meningitis, Bacterial, Ossification, Heterotopic, Osteocytes, Otosclerosis, Temporal Bone",
author = "Bloch, {Sune Land} and McKenna, {Michael John} and Joe Adams and Morten Friis",
note = "{\circledC} The Author(s) 2015.",
year = "2015",
month = "8",
doi = "10.1177/0003489415573960",
language = "English",
volume = "124",
pages = "649--54",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Co",
number = "8",

}

RIS

TY - JOUR

T1 - Labyrinthitis Ossificans

T2 - On the Mechanism of Perilabyrinthine Bone Remodeling

AU - Bloch, Sune Land

AU - McKenna, Michael John

AU - Adams, Joe

AU - Friis, Morten

N1 - © The Author(s) 2015.

PY - 2015/8

Y1 - 2015/8

N2 - INTRODUCTION: It has been suggested that remodeling of the otic capsule is highly suppressed by the action of anti-resorptive signals emanating from structures of the inner ear space. Labyrinthitis ossificans (LO) is a severe complication to bacterial meningitis and is characterized by destruction of inner ear structures by the formation of new bone. The aim of this study was to explore the impact of LO on bone remodeling of the otic capsule.MATERIAL AND METHODS: In 11 human temporal bones with extensive LO and 10 control specimens, the degree of bone remodeling was explored indirectly by estimating the viability of osteocytes in perilabyrinthine bone and the mastoid.RESULTS: The viability of osteocytes was significantly lower in the perilabyrinthine bone compared to the mastoid in both groups. However, the loss of perilabyrinthine osteocytes was the same in the 2 groups, and the presence of cartilage remnants appeared to be the same.CONCLUSION: This study indicates that the factors affecting bone remodeling of the otic capsule and the degeneration of osteocytes are not altered by wholesale destruction of inner ear soft tissue and its replacement by bone. Therefore, alternative mechanisms may be implicated in the suppression of capsular bone remodeling.

AB - INTRODUCTION: It has been suggested that remodeling of the otic capsule is highly suppressed by the action of anti-resorptive signals emanating from structures of the inner ear space. Labyrinthitis ossificans (LO) is a severe complication to bacterial meningitis and is characterized by destruction of inner ear structures by the formation of new bone. The aim of this study was to explore the impact of LO on bone remodeling of the otic capsule.MATERIAL AND METHODS: In 11 human temporal bones with extensive LO and 10 control specimens, the degree of bone remodeling was explored indirectly by estimating the viability of osteocytes in perilabyrinthine bone and the mastoid.RESULTS: The viability of osteocytes was significantly lower in the perilabyrinthine bone compared to the mastoid in both groups. However, the loss of perilabyrinthine osteocytes was the same in the 2 groups, and the presence of cartilage remnants appeared to be the same.CONCLUSION: This study indicates that the factors affecting bone remodeling of the otic capsule and the degeneration of osteocytes are not altered by wholesale destruction of inner ear soft tissue and its replacement by bone. Therefore, alternative mechanisms may be implicated in the suppression of capsular bone remodeling.

KW - Aged

KW - Aged, 80 and over

KW - Anatomy, Regional

KW - Bone Remodeling

KW - Ear, Inner

KW - Female

KW - Humans

KW - Labyrinthitis

KW - Male

KW - Mastoid

KW - Meningitis, Bacterial

KW - Ossification, Heterotopic

KW - Osteocytes

KW - Otosclerosis

KW - Temporal Bone

U2 - 10.1177/0003489415573960

DO - 10.1177/0003489415573960

M3 - Journal article

VL - 124

SP - 649

EP - 654

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

IS - 8

ER -

ID: 46013854